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The Body Covers: The 12th International AIDS Conference
Poster Session 12290: Sixteen-Week Followup of Indinavir Sulfate (Crixivan) Administered Every 8 Hours versus Every 12 Hours in Combination with Efavirenz

June 29, 1998

A note from TheBody.com: Since this article was written, the HIV pandemic has changed, as has our understanding of HIV/AIDS and its treatment. As a result, parts of this article may be outdated. Please keep this in mind, and be sure to visit other parts of our site for more recent information!

This trial is another in a series of studies looking at combinations of antiretrovirals that are easier to live with, as a result of having fewer pills, taken fewer times a day. It compared twice-daily indinavir (1,200 mg every 12 hours) in combination with twice-daily efavirenz (300 mg every 12 hours) to standard dosing of indinavir (800 mg every eight hours) combined with efavirenz dosed once-a-day. After 16 weeks of therapy, 86 percent of patients (6 out of 7) in the twice-daily group had HIV suppressed below detection (400 copies/mL) compared to 75 percent (6 out of 8) in the group receiving standard dosing of indinavir. One interesting aspect of this trial is that it looked at patient adherence to the regimen, and was able to determine that poor adherence is a major contributing factor to viral rebound.

While this is a small preliminary study, its findings should encourage researchers to continue examining combination therapies that are easier to take, without compromising efficacy.

A note from TheBody.com: Since this article was written, the HIV pandemic has changed, as has our understanding of HIV/AIDS and its treatment. As a result, parts of this article may be outdated. Please keep this in mind, and be sure to visit other parts of our site for more recent information!

Reference

Abstract: Sixteen-Week Followup of Indinavir Sulfate (Crixivan) Administered Every 8 Hours versus Every 12 Hours in Combination with Efavirenz
Authored by: Diane Havlir et al

See Also
More Research on HIV/AIDS Treatment Strategies
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Please note: Knowledge about HIV changes rapidly. Note the date of this summary's publication, and before treating patients or employing any therapies described in these materials, verify all information independently. If you are a patient, please consult a doctor or other medical professional before acting on any of the information presented in this summary. For a complete listing of our most recent conference coverage, click here.

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