Advertisement
The Body: The Complete HIV/AIDS Resource
Follow Us Follow Us on Facebook Follow Us on Twitter Download Our App
Professionals >> Visit The Body PROThe Body en Espanol
  
  • Email Email
  • Glossary Glossary
The Body Covers: The 12th International AIDS Conference
Session 286/12204: Combination Abacavir (1592, ABC)/Amprenavir (141W94) Therapy in HIV-1 Infected Antiretroviral Naïve Subjects with CD4+ Cell Counts >400 cells/mL and Viral Load >5000 copies/mL

June 29, 1998

A note from TheBody.com: Since this article was written, the HIV pandemic has changed, as has our understanding of HIV/AIDS and its treatment. As a result, parts of this article may be outdated. Please keep this in mind, and be sure to visit other parts of our site for more recent information!

Dr. Bart and colleagues presented preliminary results from this open-label study of abacavir, an experimental nucleoside analog reverse transcriptase inhibitor, and amprenavir, an experimental protease inhibitor, in 40 treatment-naïve patients.

Interim Week 24 results from this 72-week study were presented. Twenty-eight patients had reached Week 24 at the time of the analysis. Twenty-five of them, or 89%, had undetectable levels of HIV (<500 copies/mL). Thirty-eight patients had reached Week 8, and all but one of them (97%) had viral load levels below the limit of detection.

There are concerns about the side effects of these drugs, especially one known as a 'hypersensitivity reaction' (HR) that has been seen in 3% of patients enrolled on abacavir studies. The symptoms of HR include fever and nausea, malaise, and most significantly, a rash that can be life-threatening. These symptoms can appear within several days to six weeks after starting abacavir, and go away after abacavir is stopped. However, abacavir must never be started again after such a reaction -- one patient on an abacavir study has died after re-starting therapy.

A note from TheBody.com: Since this article was written, the HIV pandemic has changed, as has our understanding of HIV/AIDS and its treatment. As a result, parts of this article may be outdated. Please keep this in mind, and be sure to visit other parts of our site for more recent information!

Reference

Abstract: Combination Abacavir (1592, ABC)/Amprenavir (141W94) Therapy in HIV-1 Infected Antiretroviral Naïve Subjects with CD4+ Cell Counts >400 cells/mL and Viral Load >5000 copies/mL
Authored by: Pierre-Alexandre Bart, M.D.

See Also
HIV Medications: When to Start and What to Take -- A Guide From TheBody.com
More Research on First-Line HIV Treatment
Advertisement:
Find out how a Walgreens specially trained pharmacist can help you



  
  • Email Email
  • Printable Single-Page Print-Friendly
  • Glossary Glossary

This article was provided by The Body PRO. Copyright © Body Health Resources Corporation. All rights reserved.


Please note: Knowledge about HIV changes rapidly. Note the date of this summary's publication, and before treating patients or employing any therapies described in these materials, verify all information independently. If you are a patient, please consult a doctor or other medical professional before acting on any of the information presented in this summary. For a complete listing of our most recent conference coverage, click here.

Advertisement