Options for People With Multi-Drug Resistance
Activists have long pushed for clinical trials that combine two new drugs for people who have no active agents, and one company, Tibotec, has recently begun the first such trials, of a protease inhibitor, darunavir (TMC 114), and an NNRTI, etravirine (TMC 125).
The DUET studies allow patients to take both of these drugs, although people will be randomized to receive etravirine or placebo. So there still is a 50% chance of receiving virtual monotherapy if you have no other active drugs available. (People randomized to receive only darunavir can add etravirine after 6 months if their viral load is not controlled.)
If your genotype test shows that your HIV is resistant to most approved anti-HIV drugs and you and your health care provider feel you must change your regimen, here are some options. (Not everyone who is resistant to their meds needs to switch; there may be good reasons not to.)
Wall Street Journal Examines So-Called "Salvage Therapy" for People With AIDS Whose Illness Is Not Responding to Treatment Options
This article was provided by AIDS Community Research Initiative of America. It is a part of the publication ACRIA Update. Visit ACRIA's website to find out more about their activities, publications and services.