How protease inhibitors may cause diabetes or worsening of blood sugar control in diabetics is not known definitively. Some researchers have reported elevated levels of insulin in persons on protease inhibitors. Insulin is a hormone made by the pancreas which acts to lower blood glucose levels. Diabetes may result from inadequate secretion of insulin from the pancreas or from defects that make cells in the body less sensitive to the effects of insulin (insulin resistance). Elevated insulin levels suggest that insulin resistance is present. The body tries to compensate for this resistance by producing more insulin, and if it fails to compensate sufficiently, high glucose levels (hyperglycemia) or actual diabetes may result.
Further research is ongoing to determine the frequency of diabetes, risk factors for its development, and why it occurs. Included in this research effort is an ongoing CRIA study of responses to the oral glucose tolerance test in persons initiating protease inhibitor therapy (see Currently Enrolling Trials).
Should all persons on protease inhibitors be monitored for diabetes? There are no definitive guidelines, but it makes sense to have blood glucose levels checked periodically. Glucose levels are usually included in routine blood chemistry tests. Persons on protease inhibitors should be aware of the usual symptoms of diabetes which include: increased thirst and appetite, increased frequency of urination, unexplained weight loss, and blurry vision.