Resistance Rules - Revised

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August/September 1996

Resistance Rules - Revised

Amino acid substitutions conferring reduced sensitivity to selected protease inhibitors:

saquinavir (Invirase)	10	48	54	63
ritonavir (Norvir)	20	36	46	54	63	71	82	84	90
indinavir (Crixivan)	10	20	24	36	46	54	63	64	71	82	84	90	193
nelfinavir (Viracept)	30	36	46	63	77	88	90
141W94 (aka VX478)	10	46	47	50	84

Amino acid substitutions in HIV isolates from patients; predominant in vivo substitutions are underscored.

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