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Medications that should NOT be used with Protease

From U.S. Food and Drug Administration

December 18, 1997

A note from TheBody.com: Since this article was written, the HIV pandemic has changed, as has our understanding of HIV/AIDS and its treatment. As a result, parts of this article may be outdated. Please keep this in mind, and be sure to visit other parts of our site for more recent information!

Drug Category Invirase™ Roche
saquinavir		 Norvir™ Abbott
ritonavir		 Crixivan® Merck
indinavir		 Viracept® Agouron nelfinavir Potential Alternatives (these alternatives may not be therapeutically equivalent)
Analgesic --- meperidine
(Demerol)

piroxicam
(Feldene)

propoxyphene
(Darvon, others)

 --- --- acetaminophen (Tylenol, others)

aspirin
(Bayer, others)

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oxycodon
(Perocet, others)
Cardiovascular
(antiarrhythmic)		 --- amiodarone
(Cordarone)

encainide
(Enkaid)

flecainide
(Tambocor)

propafenone
(Rythmol)

quinidine
(various)

 --- --- very limited clinical experience
Cardiovascular
(calcium channel blocker)		 --- bepridil
(Vascor)		 --- --- very limited clinical experience
Antimycobacterial rifampin
(Rifadin, others)		 rifabutin
(Mycobutin)		 rifampin
(Rifadin, others)		 rifampin
(Rifadin, others)		 alternatives for rifabutin
(Mycobutin):

clarithromycin (Biaxin)

ethambutol (Myambutol)
Ergot Alkaloid
(vasoconstrictor)		 dihydroergotamine
(D.H.E. 45) ergotamine
(various)		 dihydroergotamine
(D.H.E. 45) ergotamine
(various)		 dihydroergotamine
(D.H.E. 45) ergotamine
(various)		 dihydroergotamine
(D.H.E. 45) ergotamine
(various)		 ---
Cold and Allergy
(antihistamine)		 astemizole
(Hismanal)

terfenadine
(Seldane)

 astemizole
(Hismanal)

terfenadine
(Seldane)

 astemizole
(Hismanal)

terfenadine
(Seldane)

 astemizole
(Hismanal)

terfenadine
(Seldane)

 loratadine
(Claritin)
Gastrointestinal cisapride
(Propulsid)		 cisapride
(Propulsid)		 cisapride
(Propulsid)		 cisapride
(Propulsid)		 very limited clinical experience
Psychotropic
(antidepressant)		 --- bupropion
(Wellbutrin)		 --- --- fluoxetine
(Prozac)

desipramine (Norpramin)
Psychotropic
(neuroleptic)		 --- clozapine
(Clozaril)

pimozide
(Orap)

 --- --- very limited clinical experience
Psychotropic
(sedative/hypnotic)		 midazolam
(Versed)

triazolam
(Halcion)

 clorazepate (Tranxene)

diazepam
(Valium)

estazolam
(ProSom)

flurazepam
(Dalmane)

midazolam
(Versed)

triazolam
(Halcion)

zolpidem
(Ambien)

 midazolam
(Versed)

triazolam
(Halcion)

 midazolam
(Versed)

triazolam
(Halcion)

 temazepam
(Restoril)

lorazepam
(Ativan)
References: Product Labeling -
  • Invirase™ (December 6, 1995)
  • Norvir™ (March 1, 1996) --
    Drug Interactions: Physicians Guide
  • Crixivan® (March 13, 1996)
  • Viracept® (March 14, 1997)

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A note from TheBody.com: Since this article was written, the HIV pandemic has changed, as has our understanding of HIV/AIDS and its treatment. As a result, parts of this article may be outdated. Please keep this in mind, and be sure to visit other parts of our site for more recent information!


  
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This article was provided by U.S. Food and Drug Administration. It is a part of the publication Protease Inhibitors Backgrounder.
 
See Also
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