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The Body: The Complete HIV/AIDS Resource
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How HIV Works in Your Body

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Anti-HIV medications battle the enzymes


  • All anti-HIV medications attack the virus inside the CD4 cell where the virus is trying to make copies of itself.
  • These medications, called enzyme inhibitors, work by blocking the enzymes used by HIV.
    Enter the good guys.
  • There are four types of anti-HIV medications:
    • NRTIs (nucleoside reverse transcriptase inhibitors)
    • NNRTIs (Non-nucleoside reverse transcriptase inhibitors)
    • PIs (Protease inhibitors)
    • Entry Inhibitors


NRTIs and NNRTIs keep HIV from changing


  • NRTIs and NNRTIs stop the enzyme "reverse transcriptase" -- the enzyme HIV uses to change and enter the CD4 cell.
  • Unable to change, HIV cannot get into the cell's command center.
  • HIV is unable to make new copies of itself.
NRTIs and NNRTIs stop HIV from changing.


PIs stop the assembly of new virus


  • PIs stop the enzyme "protease" -- which HIV uses to cut out and assemble new viral parts.
  • Although new viral parts may be produced, the parts don't go together properly.
  • The defective virus cannot go on to infect other cells.
PIs make sure that new HIV parts are not put together.





Used with permission of GlaxoSmithKline.
GlaxoSmithKline
All rights reserved.
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