Advertisement
The Body: The Complete HIV/AIDS Resource
Follow Us Follow Us on Facebook Follow Us on Twitter Download Our App
Professionals >> Visit The Body PROThe Body en Espanol
Read Now: Expert Opinions on HIV Cure Research
  
  • Email Email
  • Printable Single-Page Print-Friendly
  • Glossary Glossary

Indinavir Alert: Crixivan Warning: Keep to Three Times a Day

September 1998

A note from TheBody.com: Since this article was written, the HIV pandemic has changed, as has our understanding of HIV/AIDS and its treatment. As a result, parts of this article may be outdated. Please keep this in mind, and be sure to visit other parts of our site for more recent information!

On September 18, Merck & Co. publicly warned against taking its protease inhibitor indinavir (Crixivan) on a twice-daily dosing schedule of 1200 mg every 12 hours. The standard schedule is 800 mg three times a day, but many doctors have been converting their patients to the much easier twice-a-day administration after Merck last winter announced results of an initial pilot study of twice-daily dosing. In that study, which observed 28 volunteers for 32 weeks, 1200 mg of indinavir twice a day appeared just as active against HIV as 800 mg three times a day.

Starting last November, Merck recruited 635 volunteers without prior treatment to compare AZT/3TC plus either twice-daily or thrice-daily indinavir. For the 87 participants now out to 24 weeks, the picture is different than the first time around. Ninety-one percent on the standard regimen had viral loads under 400 compared to only 64% on the twice-daily regimen.

The pilot study results were received with skepticism because their preliminary nature said little about the durability of the response to indinavir twice a day. Many experts could not believe that this new dosing schedule would be as good as the old one. It seemed obvious that the trough blood levels of indinavir, reached at the six-hour point between doses, would be much lower than with the every eight hour, thrice-daily schedule. This would give HIV a window of opportunity to reproduce and evolve into drug-resistant strains.

While canceling the trials of twice-daily indinavir, Merck is continuing to test twice-daily indinavir combined with either ritonavir or nelfinavir. Both of these protease inhibitors have the side effect of reducing indinavir's breakdown by the liver. The result is to make indinavir more stable in the body and give a twice-daily schedule a better rationale.

Advertisement

Back to GMHC Treatment Issues September 1998 contents page.

A note from TheBody.com: Since this article was written, the HIV pandemic has changed, as has our understanding of HIV/AIDS and its treatment. As a result, parts of this article may be outdated. Please keep this in mind, and be sure to visit other parts of our site for more recent information!



  
  • Email Email
  • Printable Single-Page Print-Friendly
  • Glossary Glossary

This article was provided by Gay Men's Health Crisis. It is a part of the publication GMHC Treatment Issues. Visit GMHC's website to find out more about their activities, publications and services.
 
See Also
More on HIV Medications
More News on Indinavir (Crixivan)

Tools
 

Advertisement