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New Data from Protease Inhibitor Trials

StudyRegimenMaximum Change in CD4/Viral LoadCD4/Viral Load Change at Week 16CD4/Viral Load Change at Week 24
Indinavir/AZT
(AZT-naive, Brazil)
224 persons
median CD4: 139
median viral load: 4.4 log = 29,000 copies/ml
AZT
Indinavir
Indinavir/AZT
+40-50 cells/-0.4 log
>+100 cells/-1.2 log
>+100 cells/-1.4 log
  +0 cells/0.3 log
>+100 cells/-0.8 log
>+100 cells/-1.3 log
Indinavir/AZT
(AZT- naive, USA)
266 persons
median CD4: 258
median viral load: 4.34 log = 22,000 copies/ml
AZT
Indinavir
Indinavir/AZT
+40-50 cells/-0.4 log
+100 cells/-1.4 log
+80 cells/-1.5 log
  +0 cells/0.3 log
+100 cells/-1.2 log
+80 cells/-1.3 log
Ritonavir/AZT
(AZT-naive)
356 persons
mean CD4 count: 361
mean viral load: 4.83 log = 68,000 copies/ml
AZT
Ritonavir
AZT/Ritonavir
+10-20 cells/-0.6 log
+70-80 cells/-1.2 log
+40-50 cells/-1.2 log
+10-20 cells/-0.4 log
+70-80 cells/-1.2 log
+40-50 cells/-1.0 log
NA
NA
NA



  
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This article was provided by Gay Men's Health Crisis. It is a part of the publication GMHC Treatment Issues. Visit GMHC's website to find out more about their activities, publications and services.
 

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