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Test Positive Aware Network
The 12th Annual HIV Drug Guide

January/February 2008

Doctor's statements by Joel Gallant, M.D., M.P.H.

Activist's statements by Martin Delaney


A Quick Guide to Using This Guide

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By Jeff Berry

  • Drugs are color-coded by class; drugs are listed alphabetically within each class by brand name.

  • Fixed-dose combinations (FDC) are formulations that combine two or more drugs, and are marked "Combo Drug."

  • The Average Wholesale Price (AWP) is an industry standard that pharmacies and other buyers use to negotiate the amount they pay for drugs. The AWP is included as a way to compare drug prices. It is not what you would pay out-of-pocket.

  • Drugs included in the HIV Drug Guide are those that are FDA-approved, or available in expanded access. Note: Last year Agenerase (amprenavir) was discontinued and removed from the market (an improved formulation, Lexiva, is available which is better absorbed and requires fewer pills).

  • The side effects and drug interactions charts make it easier to quickly find some of the more common side effects associated with each drug. Always refer to the individual drug pages, the manufacturer's package insert, and your physician or pharmacist for more information on drug side effects and drug-drug interactions.

  • Our special pull-out chart allows you to easily pinpoint dosing information and food and liquid qualifications for each drug. (Intelence is missing because it was not yet approved when the chart was printed.) Refer to the drug pages or package insert for more information.

  • The U.S. Department of Health and Human Services (DHHS) Treatment Guidelines are periodically updated by a panel of experts. The complete document is available online and contains comprehensive and detailed guidelines on treatment strategies, lab tests, when to start, what to use, special populations, and co-infection.

  • Expanded versions of many of the activist's comments, including views on drug development, are available online at www.tpan.com.


Nucleoside Analog Reverse Transcriptase Inhibitors (NRTIs) or "Nukes"
Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs) or "Non-Nukes"
Dual-Class Fixed Dosed Combination
Protease Inhibitors (PIs)
Entry Inhibitors
  Integrase Inhibitor


Combivir (lamivudine/zidovudine) Emtriva (emtricitabine, FTC) Epivir (lamivudine, 3TC)

Combivir
(lamivudine/zidovudine)

Adult Single Dose:
One tablet (150 mg lamivudine, 300 mg zidovudine), twice daily

Food and liquid qualifications: No food restrictions (with or without food)

Emtriva
(emtricitabine, FTC)

Adult Single Dose*: One 200 mg capsule, once daily

Food and liquid qualifications: No food restrictions (with or without food)

Epivir
(lamivudine, 3TC)

Adult Single Dose: One 300 mg tablet, once daily; or one 150 mg tablet twice daily

Food and liquid qualifications: No food restrictions (with or without food)

Epzicom (abacavir/lamivudine) Retrovir (zidovudine, AZT) Trizivir (abacavir/lamivudine/zidovudine)

Epzicom
(abacavir/lamivudine)

Adult Single Dose:
One tablet (600 mg Ziagen, 300 mg Epivir), once daily

Food and liquid qualifications: No food restrictions (with or without food)

Retrovir
(zidovudine, AZT)

Adult Single Dose: One 300 mg tablet, twice daily

Food and liquid qualifications: No food restrictions (with or without food)

Trizivir (abacavir/lamivudine/ zidovudine)

Adult Single Dose:
One tablet (300 mg Ziagen, 150 mg Epivir, 300 mg Retrovir), twice daily

Food and liquid qualifications: No food restrictions (with or without food)

Truvada (tenofovir/emtricitabine) Videx & Videx EC (didanosine, ddI) Viread (tenofovir)

Truvada
(tenofovir/ emtricitabine)

Adult Single Dose:
One tablet (200 mg Emtriva, 300 mg Viread), once daily

Food and liquid qualifications: No food restrictions (with or without food)

Videx & Videx EC
(didanosine, ddI)

Adult Single Dose: One 400 mg capsule, once daily with adjustments for weight (see Drug Guide)

Food and liquid qualifications: Take on an empty stomach, at least one hour before or 2 hours after food or drink, except water

Viread
(tenofovir)

Adult Single Dose: One 300 mg tablet, once daily

Food and liquid qualifications: No food restrictions (with or without food)

Zerit (stavudine, d4T) Ziagen (abacavir sulfate) Rescriptor (delavirdine)

Zerit
(stavudine, d4T)

Adult Single Dose: One 40 mg capsule, twice daily with adjustments for weight (see Drug Guide)

Food and liquid qualifications: No food restrictions (with or without food)

Ziagen
(abacavir sulfate)

Adult Single Dose: Two 300 mg tablets, once daily (or one 300 mg tablet twice daily)

Food and liquid qualifications: No food restrictions (with or without food)

Rescriptor
(delavirdine)

Adult Single Dose: Two 200 mg tablets, three times a day or four 100 mg tablets, three times a day

Food and liquid qualifications: No food restrictions (with or without food)

Intelence (etravirine, TMC-125) Sustiva (efavirenz) Viramune (nevirapine)

Intelence
(etravirine or TMC-125)

Adult Single Dose:
Two 100 mg tablets twice a day

Food and liquid qualifications: Take after a meal

Sustiva
(efavirenz)

Adult Single Dose:
One 600 mg tablet, once daily or three 200 mg capsules, once daily

Food and liquid qualifications: Take on an empty stomach, or may be taken with a light, low-fat snack

Viramune
(nevirapine)

Adult Single Dose:
One 200 mg tablet, daily for the first 14 days, then one 200 mg tablet, twice daily, or two 200 mg tablets, once daily

Food and liquid qualifications: No food restrictions (with or without food)

Atripla (efavirenz, emtricitabine, tenofovir) Aptivus (tipranavir) Crixivan (indinavir)

Atripla
(efavirenz, emtricitabine,
tenofovir
)

Adult Single Dose: One tablet (Sustiva [600 mg] and Truvada [200 mg Emtriva, 300 mg Viread]), once daily

Food and liquid qualifications: Take on an empty stomach, or may be taken with a light, low-fat snack

Aptivus
(tipranavir)

Adult Single Dose: Two 250 mg capsules with two 100 mg capsules Norvir, twice daily

Food and liquid qualifications: Take with food

Crixivan
(indinavir)

Adult Single Dose:
Two 400 mg capsules, every 8 hours (almost always boosted with Norvir, see Drug Guide)

Food and liquid qualifications: Take with no food or a low-fat snack (with food with Norvir); drink at least 1.5 liters of water daily

Invirase (saquinavir) Kaletra (lopinavir/ritonavir) Lexiva (fos-amprenavir calcium)

Invirase
(saquinavir)

Adult Single Dose: Two 500 mg tablets with one 100 mg capsule Norvir, twice daily. (Or five 200 mg hard-gel capsules and 100 mg Norvir, twice daily.) Saquinavir must be dosed with Norvir.

Food and liquid qualifications: Take with food, or within two hours after a meal

Kaletra
(lopinavir/ritonavir)

Adult Single Dose:
Four tablets (200 mg lopinavir/50 mg ritonavir), once daily if on first-time HIV therapy or two 200/50 mg tablets, twice daily

Food and liquid qualifications: No food restrictions (with or without food)

Lexiva
(fos-amprenavir calcium)

Adult Single Dose: Two 700 mg tablets plus 200 mg Norvir, once daily or two 700 mg tablets, twice daily (if protease inhibitor experienced, 700 mg with 100 mg Norvir, twice daily)

Food and liquid qualifications: No food restrictions (with or without food)

Norvir (ritonavir) Prezista (darunavir) Reyataz (atazanavir sulfate)

Norvir
(ritonavir)

Adult Single Dose: Used mostly for boosting, once or twice a day with another PI

Food and liquid qualifications: Take with food, if possible

Prezista
(darunavir)

Adult Single Dose: Two 300 mg tablets plus 100 mg Norvir, twice daily

Food and liquid qualifications: Take with food

Reyataz
(atazanavir sulfate)

Adult Single Dose:
One 300 mg capsule plus 100 mg Norvir, once daily or two 200 mg capsules, once daily (see Drug Guide)

Food and liquid qualifications: Take with food

Viracept (nelfinavir) Fuzeon (enfuvirtide, T-20) Selzentry (maraviroc)

Viracept
(nelfinavir)

Adult Single Dose: Two 625 mg tablets, twice daily (or five 250 mg tablets, twice daily)

Food and liquid qualifications: Take with a meal

Fuzeon
(enfuvirtide, T-20)

Adult Single Dose: 90 mg, twice daily subcutaneous injections

Food and liquid qualifications: No food restrictions (with or without food)

Selzentry
(maraviroc)

Adult Single Dose: Available in 150 mg and 300 mg tablets; the recommended dose varies

Food and liquid qualifications: No food restrictions (with or without food)

Isentress (raltegravir)      

Isentress
(raltegravir)

Adult Single Dose: One 400 mg film-coated tablet twice a day

Food and liquid qualifications: No food restrictions (with or without food)

     

See Also
More on the First Steps to HIV Treatment
HIV Medications: When to Start and What to Take -- A Guide From TheBody.com


This article was provided by Test Positive Aware Network. It is a part of the publication Positively Aware.


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