2001-2002 Medical Management of HIV Infection. Johns Hopkins University, Baltimore, MD. 2001.

This table is a replacement for the table that was printed with a copy error on page 8 of the November 2001 issue of HEPP News. The entire Antiretroviral Agents Dosing and Administration Recommendations table is available in its correct form at www.hivcorrections.org/archives/nov01/nov2001.pdf (pages 7-8) or by emailing a request to heppnews@brown.edu.

Protease Inhibitors (PIs)
	Recommended Dose	Food Effect	Side Effects*
Indinavir (Crixivan)	800 mg q 8h Separated ddI dose by 1 hr	77%; take 1 hr before or 2 hours after meals; may take with low fat snack or skim milk	GI intolerance (10-15%); nephrolithiasis or nephrotoxicity (10-15%); headache; asthenia; dizziness; rash; metallic taste; ITP; alopecia; lab: increase indirect bilirubinemia (inconsequential) Class side effects*
Ritonavir (Norvir)	600 mg bid Separate ddI dose by 2 hr	15%; take with food if possible to improve tolerability	GI intolerance (20-40%); paresthesias-circum-oral and extremities (10%); taste perversion (10%); lab: triglycerides increase in 60% and transaminase increase in 10-15%, CPK and uric acid increase Class side effects*
Saquinavir (Invirase)	Not recommended as single PI 400 mg bid with RTV	No food effect when taken with RTV	GI intolerance (10-20%); increase Class side effects*
Saquinavir (Fortovase)	1,200 mg tid	6x; take with large meal unless taken with RTV	GI intolerance (20-30%); headache; hypoglycermia; transaminase increase Class side effects*
Amprenavir (Agenerase)	1,200 mg bid (caps) 1400 mg bid (oral solution)	High fat meal decreases AUC 20%; can be taken with or without food, but high fat meal should be avoided	GI intolerance (10-30%); rash (20-25% -- usually at 1-10 wks), Stevens-Johnson syndrome (1%); paresthesias (10-30% -- perioral or peripheral) Increase in liver function tests. Class side effects*
Nelfinavir (Viracept)	1,250 mg bid or 750 mg tid	2-3x; take with meal or snack	Diarrhea (10-30%) Class side effects*
Lopinavir + Ritonavir (Kaletra)	3 caps or 0.5 mL twice daily 4 caps bid when used with efavirenz or nevirapine	Fat increases AUC 50% to 80%; should be taken with food	GI intolerance: nausea, vomiting, diarrhea Elevated Lipids Asthenia Class side effects*
* For full information on toxicity and drug interactions for PIs and class side effects, see Chapter 4 of Bartlett J.G. and Gallant J.E. 2001-2002 Medical Management of HIV Infection. Johns Hopkins University, Baltimore, MD. 2001.

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