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HIV 101: Common Toxicities Among ARVs

June 2003

A note from TheBody.com: Since this article was written, the HIV pandemic has changed, as has our understanding of HIV/AIDS and its treatment. As a result, parts of this article may be outdated. Please keep this in mind, and be sure to visit other parts of our site for more recent information!

AgentPossible Class ToxicitiesAdditional Toxicities
NRTI
Abacavir (ABC, Ziagen)Mitochondrial toxicity (pancreatitis, peripheral neuropathy, lactic acidosis) and lipodystrophyHypersensitivity reaction
Didanosine (ddI, Videx)Mitochondrial toxicity (pancreatitis, peripheral neuropathy, lactic acidosis) and lipodystrophyPancreatitis, peripheral neuropathy
Lamivudine (3TC, Epivir)Mitochondrial toxicity (pancreatitis, peripheral neuropathy, lactic acidosis) and lipodystrophyPancreatitis
Stavudine (d4T, Zerit)Mitochondrial toxicity (pancreatitis, peripheral neuropathy, lactic acidosis) and lipodystrophyPeripheral neuropathy, pancreatitis, hepatoxicity
Zalcitabine (ddC, Hivid)Mitochondrial toxicity (pancreatitis, peripheral neuropathy, lactic acidosis) and lipodystrophyPancreatitis, peripheral neuropathy, oral apthae
Zidovudine (AZT, Retrovir)Mitochondrial toxicity (pancreatitis, peripheral neuropathy, lactic acidosis) and lipodystrophyAnemia, leukopenia, neutropenia, myositis
NtRTI
Tenofovir (TDF, Viread) Lactic acidosis
NNRTI
Delavirdine (DLV, Rescriptor)Hepatotoxicity; potential to cause rash 
Efavirenz (EFV, Sustiva)Hepatotoxicity; potential to cause rashHyperlipidemia
Nevirapine (NVP, Viramune)Hepatotoxicity; potential to cause rash 
PI
Amprenavir (APV, Agenerase)Hyperglycemia, hyperlipidemia, and lipodystrophy. Increased risk for osteopenia and osteoporosis. 
Indinavir (IDV, Crixivan)Hyperglycemia, hyperlipidemia, and lipodystrophy. Increased risk for osteopenia and osteoporosis.Hepatitis
Nelfinavir (NFV, Viracept)Hyperglycemia, hyperlipidemia, and lipodystrophy. Increased risk for osteopenia and osteoporosis. 
Ritonavir (RTV, Norvir)Hyperglycemia, hyperlipidemia, and lipodystrophy. Increased risk for osteopenia and osteoporosis.Hepatitis
Saquinavir (SQV, Invirase, Fortovase)Hyperglycemia, hyperlipidemia, and lipodystrophy. Increased risk for osteopenia and osteoporosis. 
Lopinavir/Ritonavir (LPV/RTV, Kaletra)Hyperglycemia, hyperlipidemia, and lipodystrophy. Increased risk for osteopenia and osteoporosis. 
Adapted from Bartlett, et al. 2001-2002 Medical Management of HIV Infection; and Sande, et al. The Sanford Guide to HIV/AIDS Therapy, 2002, Eleventh Edition.


Back to the HEPP Report June 2003 contents page.

A note from TheBody.com: Since this article was written, the HIV pandemic has changed, as has our understanding of HIV/AIDS and its treatment. As a result, parts of this article may be outdated. Please keep this in mind, and be sure to visit other parts of our site for more recent information!



  
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This article was provided by Brown Medical School. It is a part of the publication HEPP Report.
 
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Side Effect Chart: An Abbreviated, At-a-Glance Guide to HIV Drug Side Effects
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