PROTOCOL WATCH
Ramped dosing for TMP-SMX seems to reduce the likelihood of adverse reactions
PAUL A. VOLBERDING, M.D., EDITOR-IN-CHIEF
CASE MANAGEMENT
What should you do when triple-drug therapy begins to fail?
HARVEY J. MAKADON, M.D.
NEWSLINE
Oxandrolone for wasting syndrome: An oral anabolic steroid increases body weight and cell mass in patients with AIDS cachexia... Update: Paromomycin ineffective against cryptosporidiosis: ACTG 192 finds commonly prescribed drug no more effective than placebo... Regression of PML in an aggressively treated patient: Splenectomy and triple-drug therapy induce remission... C.D.C. reports substantial drop in AIDS deaths: First decline in annual mortality rate since 1981... Study finds treatment of pain inadequate in AIDS patients: Neuropathies particularly undertreated... Smoking increases risk of cryptococcosis: Fivefold increase in incidence seen in AIDS patients who smoke... Cidofovir for CMV retinitis: Therapeutic alternative for patients who develop resistance to ganciclovir...
OPTIMAL MEDICAL MANAGEMENT
An underdiagnosed and undertreated aspect of advanced infection
HOWARD L. ROSNER, M.D.
PULL OUT AND SAVE
Making the assessment and assigning the analgesic
