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August 1997

HIV Disease in Women and Children

A special issue on prevention and treatment of pregnant women and their offspring



EDITORIAL

Preventing Vertical Transmission: A Wise Investment

We have learned a lot about how to prevent transmission of HIV from mother to their infants, and the time to act is now
CATHERINE M. WILFERT, M.D.



OPTIMAL MEDICAL MANAGEMENT

Antiretroviral Therapy in Pregnant Women

Treatment reduces the likelihood of vertical transmission as well as maternal disease progression
BONNIE J. DATTEL, M.D.



NEWSLINE

Newsline ... Newsline ... Newsline ...

Combinations of reverse transcriptase inhibitors in children: A small study shows ZDV plus 3TC to be effective in patients who fail monotherapy ... Triple combination therapy in infants: Compelling evidence of the efficacy of early, aggressive therapy in neonates ... Risk factors and perinatal transmission: Data suggest that therapeutic strategies should emphasize reduction of viral load ... Oral ZDV may be equal to intravenous drug during delivery: Both achieve dramatic reductions in perinatal transmission rates ... Low-dose ZDV is effective in children: Optimal dose appears to be 90 mg/m2 or less ... Glaxo Wellcome makes its promising new nucleoside analog, abacavir (GW1592), available to children as well as adults ...



PULL OUT AND SAVE

U.S. Public Health Service Recommendations for Use of Antiretroviral Drugs During Pregnancy

Highlights of a task force report aimed at optimizing maternal health and reducing perinatal transmission of HIV infection



THERAPEUTIC ADVANCES

Antiretroviral Therapy in Children

The pediatric standard of care -- especially with regard to the use of protease inhibitors -- is a crazy quilt of guesswork and hopeful comparisons
PHILIP TOLTZIS, M.D., AND TIFFANI COLEMAN, R.N., N.D.




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