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February 2001

EDITORIAL

Putting an End to the Guesswork

Assays that measure the susceptibility of a particular viral isolate to particular antiretroviral agents help clinicians devise successful successor regimens for patients who are failing therapy
WILLIAM G. POWDERLY M.D., EDITOR-IN-CHIEF


OPTIMAL MEDICAL MANAGEMENT

Entering the Era of Truly Individualized Antiretroviral Therapy

By combining resistance testing with drug-level monitoring, providers will be able to individualize therapy to a degree never previously possible
ANDREW D. LUBER, PHARM.D., and W. DAVID HARDY, M.D.

&

Clinical Considerations in Therapeutic Drug Monitoring


NEWSLINE

Newsline...Newsline...Newsline...

Update: Subcutaneous interleukin-2: Investigators observe dose-related increases in CD4 counts -- without increases in HIV RNA . . . Update: Treatment of lipodystrophy: Metformin reduces insulin resistance and visceral fat deposits . . . Scrub typhus and HIV co-infection: Does O. tsugamushi inhibit syncytia formation in seropositive patients?


PULLOUT

Trekking with AIDS, Part 3: A Special Report

An advocate for people living with AIDS proves that HIV infection is no impediment to completing this country's oldest and most famous wilderness trail
DAWN AVERITT


CASE MANAGEMENT

Michael T., a Longterm Survivor Who Is Failing His Fifth Salvage Regimen

Phenotype assay results -- reproduced here -- suggest a therapeutic option for a patient who has developed high-level resistance to two classes of antiretroviral agents
ANDREW D. LUBER, PHARM.D.


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