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February 1998

EDITORIAL

A New Approach to Therapy

Can we use what we know about AIDS-resistance genes to fashion new therapies to combat HIV?
STEPHEN J. O'BRIEN, PH.D.



NEWSLINE

Newsline ... Newsline ... Newsline ...

More evidence that genes confer protection against AIDS progression: A newly discovered allele, SDF-1, offers twice the protection of other gene variants, and CCR5 slows disease progression in children as well as adults ... HAART therapy leads to resolution of MAC infection ... Adefovir, the first nucleotide analog: A novel antiretroviral agent shows early promise ... Combination d4T and 3TC in patients with prior exposure: A therapeutic option in patients who have developed resistance to ZDV ... Inadequate diet is a factor for disease progression in IVDUs ... CSF RNA levels appear to correlate with AIDS dementia ...

Plus: Highlights of the 5th Conference on Retroviruses and Opportunistic Infections: New tests for detecting viral RNA and immune response to HIV infection ... Immune reconstitution ... Where have all the OIs gone?



PULL OUT AND SAVE

Selected Clinical Trials Open to Patients with HIV Disease

An abbreviated list of open clinical trials involving various combinations of antiretroviral agents, some approved and some experimental



OPTIMAL MEDICAL MANAGEMENT

Improved Treatment of CMV Retinitis

New drugs and new strategies can inhibit disease progression
MARK A. JACOBSON, M.D.




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