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October 1998

IN MEMORIAM

We Will Prevail Together

The enduring legacy of Jonathan M. Mann and Mary Lou Clements-Mann
EDWIN BAYRD, EXECUTIVE EDITOR



OPTIMAL MEDICAL MANAGEMENT

Prophylaxis of OIs in the Age of Protease Inhibitors -- An Update

New information -- and accumulating clinical experience -- suggest that it may be possible to withdraw some types of prophylaxis without putting patients at risk of developing opportunistic infections
WILLIAM G. POWDERLY, M.D.



NEWSLINE

Newsline ... Newsline ... Newsline ...

Simultaneous initiation of three-drug regimen more effective than adding drugs sequentially: More evidence favoring an aggressive approach to therapy ... Five-drug regimen produces sharp reductions in viral load: Experimental combination may be useful in patients with high baseline HIV RNA levels ... Genotype and disease progression: A clearer picture of the role that CCR5 plays in HIV infection ... Reservoirs of HIV infection: Replication-competent virus found in tonsillar tissue ... Interleukin-2: Unfortunately, subcutaneous injections are not as effective as continuous infusion ... Infectious HIV found in genital herpes lesions: Reactivation of HSV leads to increased viral load on mucosal surfaces ...



CASE MANAGEMENT

John D., a Patient Who Has Failed All Conventional Therapies

What options do patients -- and providers -- have when salvage therapy is indicated?
HARVEY J. MAKADON, M.D.




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