The enduring legacy of Jonathan M. Mann and Mary Lou Clements-Mann
EDWIN BAYRD, EXECUTIVE EDITOR
OPTIMAL MEDICAL MANAGEMENT
New information -- and accumulating clinical experience -- suggest that it may be possible to withdraw some types of prophylaxis without putting patients at risk of developing opportunistic infections
WILLIAM G. POWDERLY, M.D.
Simultaneous initiation of three-drug regimen more effective than adding drugs sequentially: More evidence favoring an aggressive approach to therapy ... Five-drug regimen produces sharp reductions in viral load: Experimental combination may be useful in patients with high baseline HIV RNA levels ... Genotype and disease progression: A clearer picture of the role that CCR5 plays in HIV infection ... Reservoirs of HIV infection: Replication-competent virus found in tonsillar tissue ... Interleukin-2: Unfortunately, subcutaneous injections are not as effective as continuous infusion ... Infectious HIV found in genital herpes lesions: Reactivation of HSV leads to increased viral load on mucosal surfaces ...
What options do patients -- and providers -- have when salvage therapy is indicated?
HARVEY J. MAKADON, M.D.