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Antiretroviral Treatment in Developing Countries: The Peril of Neglecting Private Providers

By Ruairí Brugha

August 2003


Antiretroviral Treatment in Developing Countries: The Peril of Neglecting Private Providers

Introduction

Increased access to antiretroviral drugs is vital for developing countries with high rates of HIV infection. But unless treatment is properly controlled, these drugs could rapidly become useless.

Only 5 percent of the 5.5 million people in developing countries who need antiretroviral treatment currently receive it.1 New initiatives and global partnerships are trying to increase access to antiretroviral drugs -- for example, the International HIV Treatment Access Coalition,1 guidelines created by the World Health Organization (WHO) for scaling up antiretroviral treatment,2 and employee programs under the umbrella of the Global Business Coalition on HIV/AIDS. However, these initiatives largely ignore the fact that most poor people who suspect they have a sexually transmitted infection seek care in the private sector because of the stigma attached.3, 4 The main care providers for HIV disease in the poorest countries are therefore likely to be private medical practitioners, pharmacists, and traditional and informal providers, such as drug vendors, who are often unregulated and dispense drugs illegally.4, 5 Improper use of antiretroviral drugs may result in development of resistant HIV, so it is important to take account of private providers and regulate their behavior.


Dangers of Unregulated Prescribing

Although recent reductions in the price of [antiretroviral] drugs are welcome, the rapid increase in legal distribution will inevitably increase illegal leakage into the private sector. Evidence of uncontrolled use is already emerging in the formal and, more worryingly, informal private sector. A study from Zimbabwe in 2000 reported that a quarter of 68 private physicians were prescribing antiretroviral drugs and a quarter of 80 pharmacies were dispensing them to patients, although insurance companies did not reimburse for their use.6 The authors described prescribing practices as "therapeutic anarchy," with prescribers and dispensers using "any ARV that they could lay their hands on."6 Monotherapy, stocked by 82 percent of pharmacies, was prescribed to 17 percent of patients; and most of the 92 patients interviewed believed that antiretroviral drugs cured HIV infection.6

A survey of 21 Ugandan private medical facilities reported that only four of 17 facilities prescribing antiretroviral drugs had received CD4 and viral load results in the previous two months for 38 of the 340 patients they were monitoring.7 Tests cost US$150 to US$165 per sample. Providers had to change patients' treatments because of differences in drug costs and running out of stock. Alternative sources of antiretroviral drugs were "mainly drug donations from relatives abroad and local pharmacies."7 Of 200 HIV-positive patients referred to a specialist center in India because of poor response to antiretroviral treatment, only 10 percent had adhered to treatment; 50 percent had stopped taking the drugs on the advice of traditional healers, and 80 percent had been receiving incorrect doses.8 In India, 60 to 85 percent of primary care provision occurs in the largely unregulated formal and informal private sector.5

In Senegal, nine antiretroviral drugs were available in the informal private sector by 2002, all donations from northern countries that were sold on.9 The study reported monotherapy, dual therapy, and intermittent treatment, stating that "the patient demand is still very weak, but several sellers in the informal market confirm that they are about to develop marketing strategies to encourage their sale."9

Policymakers cannot afford to wait for conclusive evidence that private providers will soon be at the forefront of providing antiretroviral drugs in developing countries and that their treatment practices will accelerate HIV resistance to these drugs. Private providers are recognized to dominate the market in the treatment of sexually transmitted diseases.3 However, international and national policymakers have not acted on the available evidence.10


Working With the Private Sector

The public sector needs to learn to compete more effectively in delivering acceptable and high quality services for controlling HIV. Even when users recognize (correctly) that public sector services are technically superior, they choose private providers to minimize stigma.11 The public sector may therefore be the best channel for delivering short course antiretroviral drugs to prevent mother-to-child transmission of HIV. Trusted private providers, like community health workers,12 may have greater potential for providing continuity of care and supporting treatment,13 driven partly by the economic incentive to retain client loyalty. They are an untapped potential for ensuring long-term compliance.

Donors need to be more active in helping countries to fulfill their stewardship responsibilities in setting prescribing and dispensing rules (regulation), ensuring compliance (enforcement), and "exercising intelligence and sharing knowledge," to deal with this private sector.14 Lack of treatment guidelines, but crucially lack of links between private practitioners and specialists and lack of access to research evidence, were reported in Zimbabwe.6 If guidelines are to contribute to a public health approach,2 they need to take into account public health realities in resource-limited settings. Most poor countries lack two proved essentials for working with dominant and uncontrolled private sectors: financial leverage and effective enforcement of regulatory controls.5 Additional strategies are needed.


Creating Policies for Treatment

National policies need to take account of the coverage achieved by different types of providers and the profile of people that providers are serving.4 Quality of care is determined by providers' knowledge, skills, and access to resources; the influence of user demand (for accessible, acceptable, and short courses of treatment); and policies and practices for drug licensing, importation, and distribution.5 The problem facing poor countries is that poor people are more likely to use informal providers such as drug shops and vendors as they lack other affordable options.4

Policy choices will be difficult. The practices of many private providers are contrary to current policy and hard to monitor. There will be opposition from powerful professional groups to working with informal providers, and projects successful in working with unorganized individual providers are hugely resource intensive.5 Consequently, working with the more organized formal private sector -- doctors, nurses, and trained pharmacists -- is the most feasible starting point for governments. No single approach will suffice for all contexts. In settings with low public sector capacity, governments could use nongovernmental organizations to run services to control HIV and manage strategies for working with and monitoring private providers.

The public sector also needs to learn the skills of the corporate private sector in social marketing, franchising, and accreditation of provider networks. Much attention is justifiably given to the potential of companies to provide antiretroviral drugs to employees and their families. A model that combines several elements of good practice is the Direct AIDS Intervention Program, a partnership between a company, a nongovernmental organization, and a health maintenance organization in South Africa.15 Employees and their families are eligible to receive a free HIV care package including antiretroviral drugs. They can use any of the eligible private practitioners, who are supported by a team of HIV/AIDS medical specialists. However, the poorest people most at risk are not in formal employment.


Cooperation

Drug development, especially for antiretrovirals, is an uncertain and risky venture. It is in the interest of pharmaceutical manufacturers as well as the public sector that prescribing, dispensing, and adherence to treatment are optimal in order to delay the emergence of resistant HIV.

Pharmaceutical distributors have sophisticated strategies for monitoring and influencing prescribing practices, even in resource-poor settings.16 They could place these at the service of the public sector.

The goal of an AIDS-free world is too important to risk failure through ideological disputes over public or private sector approaches at the local or global level. Each can learn from the other, and the state should be the guarantor of quality, wherever people seek care.14 A sustained increase in resources to ensure access to antiretroviral drugs through long-term commitments to the Global Fund to Fight AIDS, Tuberculosis, and Malaria; investment in building public sector capacity to manage increasingly complex health systems; and the piloting and evaluation of innovative strategies for delivering antiretroviral drugs are all needed.

At the 14th International Conference on AIDS in 2002, [former South African President] Nelson Mandela talked about the window of hope offered by even a few years of additional life on antiretroviral drugs for people with HIV/AIDS. Accelerated HIV resistance due to widespread uncontrolled use in the private sector will remove that hope and threaten populations in poor and wealthy countries alike.

Ruairí Brugha is a Senior Lecturer in Public Health in the Health Policy Unit of the Department of Public Health and Policy at the London School of Hygiene and Tropical Medicine.

Editor's Note: This article originally appeared in BMJ 2003;326:1382-4 and appears here with permission from the British Medical Journal.


References

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  2. World Health Organization. Scaling up antiretroviral therapy in resource-limited settings: Guidelines for a public health approach. Geneva: WHO, 2002.

  3. Brugha R, Zwi A. Improving the quality of privately provided public health care in low and middle income countries: Challenges and strategies. Health Policy Plann 1998;13(2):107-20.

  4. Berman P. Organization of ambulatory care provision: A critical determinant of health system performance in developing countries. Bull WHO 2000;78:791-802.

  5. Smith E, Brugha R, Zwi A. Working with private sector providers for better health care. London: Options, London School of Hygiene and Tropical Medicine, 2001.

  6. Nyazema NZ, Khosa S, Landman I, Sibanda E, Gael K. Antiretroviral (ARV) drug utilization in Harare. Cent Afr J Med 2000;46(4):89-93.

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  8. Saple DG, Vaidya SB, Kharkar RD, Pandey VP, Vedrevu R, Ramnanai JP et al. Causes of ARV failure in India [abstract WePeB5860]. Proceedings of the 14th International AIDS Conference, 7-12 July 2002, Barcelona.

  9. Egrot M, Taverne B, Ciss M, Ndoye I, Epelboin A, Magaud M, et al. Antiretroviral drugs in the informal medicine trade in West Africa: the situation in Senegal [abstract TuPeE5143]. Proceedings of the 14th International AIDS Conference, 7-12 July 2002, Barcelona.

  10. Brugha R, Zwi A. Global approaches to private sector provision: where is the evidence? In: Lee K, Buse K, Fustukian S, eds. Health policy in a globalising world. Cambridge: Cambridge University Press, 2002:63-78.

  11. Benjarattanaporn P, Lindan CP, Mills S, Barclay J, Bennett A, Mugrditchian D, et al. Men with sexually transmitted diseases in Bangkok: where do they go for treatment and why? AIDS 1997;11(suppl 1):S87-95.

  12. Farmer P, Leandre F, Mukherjee J, Gupta R, Tarter L, Kim JY. Community-based treatment of advanced HIV disease: introducing DOT-HAART (directly observed therapy with highly active antiretroviral therapy). Bull WHO 2001;79:1145-51.

  13. Balambal R. Profile of DOT providers in the private sector. Indian J Tuberc 2001;48:73-6.

  14. World Health Organization. The world health report 2000. Health systems: improving performance. Geneva: WHO, 2000.

  15. Business Fights AIDS. Member profile: Abbott Laboratories Workplace Program.

  16. Kamat VR, Nichter M. Monitoring product movement: An ethnographic study of pharmaceutical sales representatives in Bombay, India. In: Bennett S, McPake B, Mills A, eds. Private health providers in developing countries. London: Zed Books, 1997:124-40.




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