An Overview of Cimduo (Lamivudine/Tenofovir Disoproxil Fumarate)
April 13, 2018
Brand Name: Cimduo
Cimduo can cause serious, life-threatening side effects. These include a buildup of lactic acid in the blood (lactic acidosis), severe liver problems, and new or worse kidney problems.
Contact your health care provider right away if you have any of the following symptoms that could be signs of lactic acidosis:
Contact your health care provider right away if you have any of the following symptoms that could be signs of liver problems:
If you have both HIV and hepatitis B virus infection (HBV) and take Cimduo, your HBV infection may get worse (flare up) if you stop taking Cimduo. To help avoid this, take Cimduo exactly as prescribed. Do not run out of Cimduo or stop taking Cimduo without talking to your health care provider.
Worsening of liver disease (sometimes resulting in death) has occurred in people being treated for hepatitis C virus infection (HCV) taking HIV medicines and interferon alfa with or without ribavirin. If you are taking Cimduo and interferon alfa with or without ribavirin and you have any new symptoms, tell your health care provider.
Some people taking Cimduo have developed new or worse kidney problems, including kidney failure. Your health care provider may do blood and urine tests to check your kidneys before and during treatment with Cimduo.
Contact your health care provider right away if you have any of the following symptoms that could be signs of kidney problems:
While taking Cimduo, it is important to keep all of your appointments with your health care provider.
What Is Cimduo?
Cimduo is a prescription medicine approved by the U.S. Food and Drug Administration (FDA) to treat HIV infection in adults and children weighing at least 77 pounds (35 kg). Cimduo is always used in combination with other HIV medicines.
Cimduo contains the following two different medicines combined in one pill:
NRTIs block an HIV enzyme called reverse transcriptase. (An enzyme is a protein that starts or increases the speed of a chemical reaction.) By blocking reverse transcriptase, NRTIs prevent HIV from multiplying and can reduce the amount of HIV in the body.
HIV medicines can't cure HIV/AIDS, but taking a combination of HIV medicines (called an HIV regimen) every day helps people with HIV live longer, healthier lives. HIV medicines also reduce the risk of HIV transmission. If you are taking HIV medicines, including Cimduo, don't cut down on, skip, or stop taking them unless your health care provider tells you to.
What Should I Tell My Health Care Provider Before Taking Cimduo?
Before taking Cimduo, tell your health care provider:
How Should I Take Cimduo?
Cimduo comes in tablet form. Each tablet contains:
Take Cimduo according to your health care provider's instructions.
Take Cimduo with or without food.
Always take Cimduo in combination with other HIV medicines.
If you take too much Cimduo, contact your health care provider or local poison control center (1-800-222-1222) right away, or go to the nearest hospital emergency room.
For more information on how to take Cimduo, see the FDA drug label from Drugs@FDA.
What Should I Do if I Forget a Dose?
If you miss a dose of Cimduo, take the missed dose as soon as you remember it. But if it is almost time for your next dose, skip the missed dose and just take your next dose at the regular time. Do not take two doses at the same time to make up for a missed dose.
What Side Effects Can Cimduo Cause?
Cimduo may cause side effects. Many side effects from HIV medicines, such as nausea or occasional dizziness, are manageable. See the AIDSinfo fact sheet on HIV Medicines and Side Effects for more information.
Some side effects of Cimduo can be serious. Serious side effects of Cimduo include a buildup of lactic acid in the blood (lactic acidosis), severe liver problems, and new or worse kidney problems. (See the WARNING box above.)
Other possible side effects of Cimduo include:
Tell your health care provider if you have any side effect that bothers you or that does not go away.
These are not all the possible side effects of Cimduo. To learn more about possible side effects of Cimduo, read the drug label or package insert or talk to your health care provider or pharmacist.
You can report side effects to FDA at 1-800-FDA-1088 (1-800-332-1088) or online at www.accessdata.fda.gov/scripts/medwatch/.
How Should Cimduo Be Stored?
Where Can I Find More Information About Cimduo?
More information about Cimduo is available:
Robert J. Coury Global Center
The above Patient Version drug summary is based on the following FDA label(s): Tablet (film coated).
[Note from TheBody: This article was created by AIDSinfo, who last updated it on Apr. 5, 2018. We have cross-posted it with their permission.]
This article was provided by AIDSinfo. Visit the AIDSinfo website to find out more about their activities and publications.
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