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'U=U': What's It All About?

February 21, 2018

The Consensus Statement of the Prevention Access Campaign, pushed forward by a dedicated group of people living with HIV, celebrates the fact that "undetectable equals untransmittable" (or U=U). This revolutionary statement acknowledges that when a person taking antiretroviral treatment has an ongoing undetectable viral load and is engaged in care, they do not transmit HIV to their sexual partners.

Here is why supporting U=U is important:

1. The Science Supports It (and The Scientists Do Too)!

We now know that people who start treatment as soon as possible after becoming HIV-positive can live long, healthy lives, and are less likely to develop HIV-related conditions or other serious health issues.

We also know that taking treatment to maintain an undetectable viral load has significant prevention benefits. In July 2016, two large studies (PARTNER and HPTN 052) published final results showing that not a single HIV transmission occurred between serodiscordant sexual partners when the person living with HIV was on treatment and had an undetectable viral load. The Prevention Access Campaign was quick to turn this new evidence into a simple and meaningful message (U=U). Researchers from all the major studies endorsed this message.

So why have others, CATIE included, been slower to accept this game-changing language? The idea of "zero risk" is uncomfortable to many because it is impossible for research to ever conclude that a risk is zero. Statistically, we cannot rule out that a very small risk may exist, no matter what the data show us. However, focusing on the possibility of a very rare event can also be misleading. In this case, a large body of evidence is telling us that people with undetectable viral loads do not transmit HIV, and in research jargon we say that the risk is negligible (meaning insignificant or not worth considering).

But what does negligible mean to the average person? Negligible may be an accurate word but it is not a suitable message. If the risk is negligible then we must be willing to accept that it is not important.

Related: HIV Undetectable = Untransmittable (U=U) Fact Sheet


2. People Living With HIV Need to Hear This Message

It is important for people living with HIV to hear this message so they can be confident in their ability to have healthy sex lives. People living with HIV continue to face stigma that affects their lives in many ways. By continuing to focus on a risk that is negligible, we do nothing to combat HIV-related stigma. The U=U message can reduce HIV stigma by removing the fear that people living with HIV are "infectious" and "risky" sex partners.

3. U=U Is a Smart HIV Prevention Message

HIV-negative people need to know that an HIV-positive person who is on treatment and engaged in care, and maintains an undetectable viral load, is a very safe sexual partner because their HIV is diagnosed and the virus is controlled. This is counter to what prevention messaging said for years, where the HIV-negative partners of people living with HIV were considered to be at highest risk. We now know that the majority of HIV transmissions come from people who are living with HIV and don't know it (the undiagnosed). This paradigm shift requires us to take up new messages that clearly communicate where the risk actually lies -- not with HIV-diagnosed people who have and maintain undetectable viral loads.

More Info

Declare your endorsement of U=U here.

Camille Arkell is the knowledge specialist of biomedical science of prevention at CATIE.

[Note from TheBody: This article was originally published by CATIE in Dec., 2017. We have cross-posted it with their permission.]

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This article was provided by Canadian AIDS Treatment Information Exchange. Visit CATIE's Web site to find out more about their activities, publications and services.

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