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Standard Practice: DHHS HIV Treatment Guidelines for First-Time Therapy

May 5, 2017

Most Patients New to Antiretroviral Therapy Should Start on One of Six Regimens

A regimen should be individualized on the basis of virologic efficacy (suppression of viral load to less than 50 copies per mL), toxicity, pill burden, dosing frequency, drug-drug interaction potential, resistance testing results, comorbid conditions (such as kidney disease, hepatitis B or C, etc.), and cost. More details including the strength of each recommendation and those for pregnant women are in the documents from the U.S. Department of Health and Human Services (DHHS) online. AIDSinfo has mobile applications that allow access to federally approved HIV/AIDS treatment and research information and are offered free of charge, including a Guidelines app, at

Most patients new to antiretroviral therapy should start on one of six regimens, based on two types of combination regimens

Recommended regimen options

Alternative regimen options

Other antiretroviral regimen options


  1. 3TC may be substituted for FTC , or vice versa.
  2. Only for patients with pre-antiretroviral therapy CrCl ≥30 mL/min
  3. Only for patients with pre-antiretroviral therapy CrCl ≥70 mL/min
  4. Only for patients who are HLA -B*5701 negative
  5. Only for patients with pre-treatment HIV RNA <100,000 copies/mL and CD4 cell count >200 cells/mm3
  6. Only for patients who are HLA -B*5701 negative and with pre-treatment HIV RNA <100,000 copies/mL

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This article was provided by Positively Aware. Visit Positively Aware's website to find out more about the publication.

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