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Down the Road: New Drugs, New Treatment Strategies and Other Changes Coming Your Way

May 5, 2017

Drug Types

  • HIV drug in development
  • Generic HIV drug
  • Hepatitis C drug in development


raltegravir QD A once-daily dose of Isentress. Approval expected in May.

ibalizumab A monoclonal antibody entry inhibitor given by infusion; an injectible may become available. Approval expected in June.

sofosbuvir/valpatasvir/voxilaprevir (GS-9857) A single-tablet regimen (STR) made up of direct-acting antivirals, two of them pangenotypic.

glecaprevir/pibrentasvir A pangenotypic regimen with two direct-acting antivirals.



bictegravir/emtricitabine/tenofovir alafenamide (GS-9883) An STR containing an integrase inhibitor (INSTI) that does not require boosting.

darunavir/cobicistat/tenofovir alafenamide/emtricitabineThe first single-tablet regimen containing a protease inhibitor.

fostemsavirAn HIV entry inhibitor that targets a different step of the viral lifecycle, it offers promise for individuals with virus that has become highly resistant to other HIV drugs.

doravirine/tenofovir disoproxil fumarate/lamivudine A single-tablet regimen containing a non-nuke that may work in those who have developed resistance to other non-nukes, with no food restrictions.

dolutegravir/rilpivirine New co-formulation of already approved INSTI and non-nuke; first STR using only two drugs.

Sustiva (efavirenz) expected to go generic first quarter.

efavirenz/tenofovir disoproxil fumarate/lamivudine expected to be available as generic first quarter; STR similar to Atripla.

Tenofovir disoproxil fumarate/lamivudine expected to be available as generic first quarter; fixed-dose combination similar to Truvada. Not studied or recommended for use as PrEP.


cabotegravir/rilpivirine LA A long-acting injectable containing an INSTI and an NNRTI.

Prezista (darunavir)goes generic.


Emtriva (emtricitabine) goes generic.

Truvada (tenofovir disoproxil fumarate/emtricitabine) goes generic.

Atripla (efavirenz/tenofovir disoproxil fumarate/ emtricitabine) goes generic.

Information courtesy of the Fair Pricing Coalition. For more, go to

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Drugs in Development: Other New Drugs

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This article was provided by Positively Aware. Visit Positively Aware's website to find out more about the publication.

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