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Information

FDA-Approved HIV Medicines

March 19, 2018

Treatment with HIV medicines is called antiretroviral therapy (ART). ART is recommended for everyone with HIV. People on ART take a combination of HIV medicines (called an HIV regimen) every day. A person's initial HIV regimen generally includes three HIV medicines from at least two different drug classes.

ART can’t cure HIV, but HIV medicines help people with HIV live longer, healthier lives. HIV medicines also reduce the risk of HIV transmission.

The following table lists HIV medicines approved by the U.S. Food and Drug Administration (FDA) for the treatment of HIV infection in the United States. The HIV medicines are listed according to drug class and identified by generic and brand names. Click on a drug name to view information on the drug from the AIDSinfo Drug Database. Or download the AIDSinfo Drug Database app to view the information on your Apple or Android devices.

To see a timeline of all FDA approval dates for HIV medicines, view the AIDSinfo FDA Approval of HIV Medicines infographic.


FDA-Approved HIV Medicines
Drug ClassGeneric Name
(Other Names and Acronyms)
Brand NameFDA Approval Date
Nucleoside Reverse Transcriptase Inhibitors (NRTIs)
NRTIs block reverse transcriptase, an enzyme HIV needs to make copies of itself. abacavir
(abacavir sulfate, ABC)
Ziagen December 17, 1998
emtricitabine
(FTC)
Emtriva July 2, 2003
lamivudine
(3TC)
Epivir November 17, 1995
tenofovir disoproxil
fumarate

(tenofovir DF, TDF)
Viread October 26, 2001
zidovudine
(azidothymidine, AZT, ZDV)
Retrovir March 19, 1987
Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs)
NNRTIs bind to and later alter reverse transcriptase, an enzyme HIV needs to make copies of itself.
efavirenz
(EFV)
Sustiva September 17, 1998
etravirine
(ETR)
Intelence
January 18, 2008
nevirapine
(extended-release nevirapine, NVP)
Viramune
June 21, 1996
Viramune XR (extended release)
March 25, 2011
rilpivirine
(rilpivirine hydrochloride, RPV)
Edurant May 20, 2011
Protease Inhibitors (PIs)
PIs block HIV protease, an enzyme HIV needs to make copies of itself
atazanavir
(atazanavir sulfate, ATV)
Reyataz June 20, 2003
darunavir
(darunavir ethanolate, DRV)
Prezista June 23, 2006
fosamprenavir
(fosamprenavir calcium, FOS-APV, FPV)
Lexiva October 20, 2003
ritonavir
(RTV)

*Although ritonavir is a PI, it is generally used as a pharmacokinetic enhancer as recommended in the Guidelines for the Use of Antiretroviral Agents in HIV-1-Infected Adults and Adolescents and the Guidelines for the Use of Antiretroviral Agents in Pediatric HIV Infection.

Norvir
March 1, 1996
saquinavir
(saquinavir mesylate, SQV)
Invirase
December 6, 1995
tipranavir
(TPV)
Aptivus
June 22, 2005
Fusion Inhibitors
Fusion inhibitors block HIV from entering the CD4 cells of the immune system.
enfuvirtide
(T-20)
Fuzeon
March 13, 2003
CCR5 Antagonists
CCR5 antagonists block CCR5 coreceptors on the surface of certain immune cells that HIV needs to enter the cells.
maraviroc
(MVC)
Selzentry
August 6, 2007
Integrase Inhibitors
Integrase inhibitors block HIV integrase, an enzyme HIV needs to make copies of itself.
dolutegravir
(DTG)
Tivicay
August 13, 2013
raltegravir
(raltegravir potassium, RAL)
Isentress


Isentress HD
October 12, 2007

May 26, 2017
Post-Attachment Inhibitors
Post-attachment inhibitors block CD4 receptors on the surface of certain immune cells that HIV needs to enter the cells.
ibalizumab
(Hu5A8, IBA, Ibalizumab-uiyk, TMB-355, TNX-355)
Trogarzo
March 6, 2018
Pharmacokinetic Enhancers
Pharmacokinetic enhancers are used in HIV treatment to increase the effectiveness of an HIV medicine included in an HIV regimen.
cobicistat
(COBI)
Tybost
September 24, 2014
Combination HIV Medicines
Combination HIV medicines contain two or more HIV medicines from one or more drug classes.
abacavir and lamivudine
(abacavir sulfate / lamivudine, ABC / 3TC)
Epzicom
August 2, 2004
abacavir, dolutegravir, and lamivudine
(abacavir sulfate / dolutegravir sodium / lamivudine, ABC / DTG / 3TC)
Triumeq August 22, 2014
abacavir, lamivudine, and zidovudine
(abacavir sulfate / lamivudine / zidovudine, ABC / 3TC / ZDV)
Trizivir
November 14, 2000
atazanavir and cobicistat
(atazanavir sulfate / cobicistat, ATV / COBI)
Evotaz
January 29, 2015
bictegravir, emtricitabine, and tenofovir alafenamide
(bictegravir sodium / emtricitabine / tenofovir alafenamide fumarate, BIC / FTC / TAF)
Biktarvy
February 7, 2018
darunavir and cobicistat
(darunavir ethanolate / cobicistat, DRV / COBI)
Prezcobix
January 29, 2015
dolutegravir and rilpivirine
(dolutegravir sodium / rilpivirine hydrochloride, DTG / RPV)
Juluca
November 21, 2017
efavirenz, emtricitabine, and tenofovir disoproxil fumarate
(efavirenz / emtricitabine / tenofovir DF, EFV / FTC / TDF)
Atripla July 12, 2006
elvitegravir, cobicistat, emtricitabine, and tenofovir alafenamide fumarate
(elvitegravir / cobicistat / emtricitabine / tenofovir alafenamide, EVG / COBI / FTC / TAF)
Genvoya November 5, 2015
elvitegravir, cobicistat, emtricitabine, and tenofovir disoproxil fumarate
(QUAD, EVG / COBI / FTC / TDF)
Stribild August 27, 2012
emtricitabine, rilpivirine, and tenofovir alafenamide
(emtricitabine / rilpivirine / tenofovir AF, emtricitabine / rilpivirine / tenofovir alafenamide fumarate, emtricitabine / rilpivirine hydrochloride / tenofovir AF, emtricitabine / rilpivirine hydrochloride / tenofovir alafenamide, emtricitabine / rilpivirine hydrochloride / tenofovir alafenamide fumarate, FTC / RPV / TAF)
Odefsey March 1, 2016
emtricitabine, rilpivirine, and tenofovir disoproxil fumarate
(emtricitabine / rilpivirine hydrochloride / tenofovir disoproxil fumarate, emtricitabine / rilpivirine / tenofovir, FTC / RPV / TDF)
Complera August 10, 2011
emtricitabine and tenofovir alafenamide
(emtricitabine / tenofovir AF, emtricitabine / tenofovir alafenamide fumarate, FTC / TAF)
Descovy April 4, 2016
emtricitabine and tenofovir disoproxil fumarate
(emtricitabine / tenofovir DF, FTC / TDF)
Truvada August 2, 2004
lamivudine and zidovudine
(3TC / ZDV)
Combivir September 27, 1997
lopinavir and ritonavir
(ritonavir-boosted lopinavir, LPV/r, LPV / RTV)
Kaletra September 15, 2000


This fact sheet is based on information from the following sources:

[Note from TheBody.com: This article was created by AIDSinfo, who last updated it on March 19, 2018. We have cross-posted it with their permission.]


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