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Atazanavir, Raltegravir and Darunavir Virologically Equivalent in Naive Patients but Significant Differences for Tolerability: Results From ACTG 5257

March 24, 2014

Primary results from the ACTG 5257 study shifted the assumed relative parity between three of the preferred first-line combinations in US DHHS guidelines. Raphael Landovitz from University of California Los Angeles, presented results at CROI 2014 from this large randomised open label study with over 1800 treatment naive participants. [1]

The study was designed based on a hypothesis of equivalence for the three groups, with 90% power to define any pair-wise comparison.

Equivalence was defined based on cumulative incidence of events at 96 weeks if the 97.5% CI for results fell within +/-10% margin. Superiority required the upper limit of the 97.5% CI to be greater than 10% and the lower limit greater than zero. All three study groups used

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More News and Research on Atazanavir (Reyataz)

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