Hepatitis C Remains Major Problem for HIV Patients Despite Antiretroviral Therapy
March 18, 2014
This article was reported by Infection Control Today.
Infection Control Today reported that the risk of serious liver disease from hepatitis C virus (HCV) infection is high for HCV/HIV-coinfected patients, regardless of whether they receive antiretroviral therapy (ART). To investigate whether ART slows liver fibrosis connected with HCV, researchers from the Perelman School of Medicine at the University of Pennsylvania (UPenn) reviewed electronic medical records of 4,280 HCV/HIV-coinfected patients who were receiving ART, and 6,079 HCV-only patients treated from 1997 through 2010.
Liver disease presents in two stages: compensated, when the liver can function normally by compensating for damage; and decompensated, when the liver can no longer function normally due to widespread damage. Findings indicated that the coinfected patients had an 80-percent higher rate of decompensated cirrhosis than patients with HCV only. When ART controlled the HIV in coinfected patients, they experienced a 60-percent higher rate of serious liver disease than patients with HCV only. Also, decompensation rates were higher for coinfected patients with advanced liver fibrosis, severeView Full Article
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