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HPV Associated With Increased Risk of HIV in Men

November 26, 2013

This article was reported by Science Daily.

Science Daily reports on a study that shows a link between human papillomavirus (HPV) and an increased HIV risk in men. The researchers, including Jennifer Smith, Ph.D., M.P.H., research associate professor with the Gillings School of Global Public Health and member of the University of North Carolina Lineberger Comprehensive Cancer Center, and Anne Rositch, PhD, MSPH, assistant professor with the University of Maryland School of Medicine, analyzed data from a study of 2,519 Kenyan men. The men were participants in a randomized clinical trial from 2002 to 2007 in Kisumu, Kenya, to determine the effectiveness of circumcision to reduce HIV transmission. During the trial, 61 men became HIV-positive.

Study participants with at least one occurrence of HPV had double the risk of becoming HIV-positive, and those with three or more HPV infections had three times the risk of getting HIV. This was true for both circumcised and uncircumcised men. Rositch questioned whether there is a role for HPV vaccine to reduce risk of HIV. Smith noted that it would be important to link HPV vaccination status with HIV incidence databases to determine the impact of HPV vaccination coverage on incidence of new HIV infections.

The full report, "Risk of HIV Acquisition Among Circumcised and Uncircumcised Young Men With Penile HPV Infection," was published in the journal AIDS (2013; doi: 10.1097/QAD.0000000000000092).

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