Print this page    •   Back to Web version of article

Targeting Reactivated HIV Using Natural Killer Cells: Another Potential Cure Strategy (Video)

By Warren Tong

September 11, 2013

"A lot of these strategies for [an HIV] cure involve waking up the virus in some way, reactivating the transcription from the stably integrated virus, but then the next question is what will eliminate that cell now that you've woken the sleeping virus?" asks Eileen Scully, M.D., Ph.D., from The Ragon Institute of MGH, MIT and Harvard.

In this interview, Scully sits down with Fred Schaich, of the International Foundation for Alternative Research in AIDS (IFARA), to discuss her work training the natural killer (NK) cells of the innate immune system to recognize and eliminate HIV, as part of a cure strategy.

Because of HIV's elusiveness and ability to subdue the body's immune responses, Scully hopes to use subtle stress molecules to help identify HIV once it's reactivated from the hidden reservoirs.

"The approach I'm going to try to take is to couple the reactivation with an inhibitor of Nef, which is an accessory protein of HIV to see if I can maximize expression of these stress molecules to allow elimination of these cells very early, before you have full production of intact virions," Scully explains.

Watch the video to learn more:



The video above has been posted on TheBodyPRO.com with permission from our partners at the International Foundation for Alternative Research in AIDS (IFARA). Visit IFARA's website or YouTube channel to watch more video interviews from the conference, as well as earlier meetings.

Warren Tong is the research editor for TheBody.com and TheBodyPRO.com.

Follow Warren on Twitter: @WarrenAtTheBody.


Copyright © 2013 Remedy Health Media, LLC. All rights reserved.




This article was provided by TheBodyPRO.com. It is a part of the publication The 7th International AIDS Society Conference on HIV Pathogenesis, Treatment and Prevention. You can find this article online by typing this address into your Web browser:
http://www.thebody.com/content/72662/targeting-reactivated-hiv-using-natural-killer-cel.html

General Disclaimer: TheBody.com is designed for educational purposes only and is not engaged in rendering medical advice or professional services. The information provided through TheBody.com should not be used for diagnosing or treating a health problem or a disease. It is not a substitute for professional care. If you have or suspect you may have a health problem, consult your health care provider.