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Razing the House of Cards: The Discovery of HAART and the Push for Evidence-Based HIV Treatment

Spring 2013

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This is the third in a series looking back at the first two decades of TAG's work to speed up AIDS research. In Part I: TAG's early campaigns to reform the National Institutes of Health (NIH) AIDS research, boost the federal budget, and revitalize HIV basic science research. In Part II: TAG's response to bad drugs, badly designed clinical trials, and inadequate surrogate markers. Here we look at the rise of highly active antiretroviral therapy (HAART) and the push for evidence-based HIV treatment.

The approval of therapies based on inadequate, ambiguous, uninterpretable or incomplete data offers severe and potentially insurmountable difficulties in the future evaluation of new treatments. This is the deck with which the current therapeutic house of cards was built.

-- Spencer Cox, Testimony before the FDA Antiviral Drugs Advisory Committee regarding accelerated approval of stavudine (d4T), May 20, 1994


Prologue

As we pointed out in the previous article in this series about TAG's accomplishments in its first two decades, the early years of antiretroviral therapy (ART) development recalled Matthew Arnold's "Dover Beach": "And we are here as on a darkling plain / Swept with confused alarms of struggle and flight, where ignorant armies clash by night." The disappointments of the early monotherapy and dual-therapy years between 1987, which saw U.S. Food and Drug Administration (FDA) approval of AZT (Retrovir), and 1995, which saw that of the first protease inhibitor, saquinavir, were succeeded by a difficult-to-believe series of breakthroughs in viral-load monitoring, clinical trials design, and rapid development of new molecules, which came together in 1996 to form the breakthrough known as highly active antiretroviral therapy, or HAART.

The development of HAART, which first came to fruition after fifteen years of basic and ten years of clinical research on HIV treatment, was not rapid, preordained, linear -- nor was it always logical. From the contemporary vantage point, with over 32 new chemical entities (NCEs) and fixed-dose combination (FDC) therapies approved by the FDA, it is not always clear what combination of activism, industry, regulation, and research was required to lead to this discovery, which has now resulted in over 8 million people around the world receiving relatively safe, unusually effective combination therapy for a lifelong infectious and almost incurable disease, HIV infection.

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Clinical drug development for HIV before HAART can be roughly divided into three periods:

  1. The first period of HIV research (1981-85) was characterized by its epidemiological identification, the naming (and often, shaming) of risky behaviors and groups, the identification of a causative agent (Paris, 1983; Bethesda, 1984; and San Francisco, 1984), the deployment of an antibody-based blood test to protect the blood supply (1985), and the surprising discovery that an old discarded cancer drug, azidothymidine (AZT), was active in vitro (1984) and in vivo (1985-86) against HIV infection. Most research was academic, carried out at prestigious institutions such as the Insitut Pasteur, where HIV was first discovered, the National Institutes of Health (NIH), and at centers in hard-hit cities such as Los Angeles, New York, and San Francisco.
  2. The second period of research (1985-90) can be described as the heyday of AZT. First licensed in 1986, it was the only FDA-approved drug for six years -- until didanosine's (ddI's) approval in mid-1991 -- and the only "active" HIV drug until the ddI parallel track was launched after national activist pressure in mid-1989. The AZT monopoly price was obscene, at $10,000 a year, the dose was monumentally too high, at 1,500 milligrams/day (250 mg every four hours), causing often-fatal anemia and disabling muscle weakness, and the drug's effects wore off as resistance emerged after a few weeks to months. The advent of AZT was either a godsend for the new NIH-funded AIDS Clinical Trials Group (ACTG) or a curse, for AZT initially consumed almost 80 percent of the new extramural chain of academic groups' budget, time, and patients. Some studies (ACTG 001, in people with HIV and Kaposi's sarcoma) might have been useful, had they been published; others (ACTG 002, comparing two doses) helped -- eventually, after pressure from ACT UP -- bring down AZT's dose to 600 mg (300 mg twice daily); and still others (ACTG 016, in "AIDS-related complex" and ACTG 019, in earlier HIV infection), stopped early, led to the premature and later discredited (Anglo-French Concorde study, 1993) recommendation that all those with HIV and CD4 counts below 500 cells/mm3 commence therapy.

    Thousands probably took the drug too early, developing resistance; thousands of others suffered unnecessary toxicities; and some probably benefited from AZT long enough to obtain other therapies. But it was a very mixed bag. And for the next few years, most of the clinical trials action seemed to be on AZT-like drugs such as ddI (FDA approved in 1991), zalcitabine (ddC; 1992), stavudine (d4T; 1994), and lamivudine (3TC; 1995). All but AZT were approved based on small and short-term changes in parameters such as CD4 counts (ddI was notoriously approved based on a small increase of just 10 CD4 cells that lasted for a matter of weeks), weight gain, and improved Karnofsky performance score. But the obvious profitability of AZT soon induced other companies to enter the drug discovery area, and some began exploring targets different from AZT.

    Finally, this period saw the almost complete exclusion of research on the AIDS-related infections and cancers that were actually the proximate cause of death for most people with AIDS -- conditions such as Pneumocystis carinii pneumonia (PCP), cytomegalovirus (CMV) retinitis and colitis, cerebral toxoplasmosis, cryptococcal meningitis, disseminated candidiasis, Kaposi's sarcoma (KS), B-cell lymphomas, and so on. There were many potential treatments and even preventive agents for these conditions, but the NIH-funded efforts ignored most of them. Community-based groups sprung up in San Francisco, New York, and elsewhere to study some of these preventive and therapeutic approaches to opportunistic infections (OIs) and also to study agents that did not have clearly demonstrated and biologically plausible anti-HIV mechanisms of activity, such as AL-721, Ampligen, dextran sulfate, isoprinosine, ribavirin, or the notorious trichosanthin (Chinese cucumber root, a.k.a. "Compound Q").

    There was also an interest in treating AIDS with immunologically active agents such as alpha interferon, gamma interferon, interleukin-2 (IL-2), and some more-or-less quack approaches like compounds such as "Imreg-1" and "Imreg-2" (I will never forget Spencer Cox sitting at a table at the East Village diner Odessa -- it could have been Leshko's -- asking Imreg-1's "discoverer" and manufacturer, "What's actually in the drug, Dr. Gottlieb?" and our dismay when the response was, "We don't actually know; it's a made from a leukocyte cell lysate [i.e., by grinding up blood cells and extracting something somehow]."
  3. The third period of HIV treatment research (1990-95) followed directly upon the ddI parallel track and ACT UP's "Storm the NIH" demo, which led not only to the full representation of activists and people with HIV on all the ACTG research committees, but to much accelerated and expanded research to prevent and treat AIDS-related opportunistic infections and cancers, such that by the mid-1990s many of them could be effectively prevented (PCP, disseminated fungal disease, toxoplasmosis), or at least treated in some cases (cutaneous KS, some B-cell lymphomas, CMV). The ACTG tooled around endlessly with various one- and two-drug combinations, usually nucleoside reverse transcriptase inhibitors only, sometimes adding in another class, often because its sponsors (e.g., Roche and Boehringer Ingelheim) lacked the guts or resources to self-develop the drug. The nadir of the period was the debacle of ACTG 155 at Berlin in mid-1993. By the end of 1995, however, some combination studies (ACTG 175) demonstrated clinical benefit, while other new agents -- ritonavir from Abbott, indinavir from Merck, and nelfinavir from Agouron -- began to show unexpected potency when measured with new quantitative viral-load assays.


The Beginning of the Modern Era

Soon after AZT's approval by the FDA in March 1987, it became clear that its benefits were transient and limited by severe anemia and other toxicities, and that treatment failure was associated with the emergence of HIV resistant to the drug. Thus, even in 1989, it seemed obvious to Burroughs Wellcome's leading virologist, David Barry, who led the AZT development team, that "you're going to have four or five drugs for the OIs and two, three and maybe four drugs for antivirals."

Dr. Barry's prediction was right, and a number of companies began fortifying their pipelines. Manufacturers either bought potential HIV agents, as did Bristol-Myers with ddI and Hoffmann-La Roche with ddC; licensed them, as Bristol did with d4T; or set out to modify existing renin inhibitors (a class of blood pressure medications industry was attempting to develop from the 1970s on) to develop aspartic protease inhibitors (PIs), that could bind and inhibit the protease enzyme of HIV-1. Researchers from a number of companies including Abbott, Merck, and Roche began efforts to crystallize the HIV-1 protease enzyme and to screen compounds that blocked its activity, as did the National Cancer Institute (NCI).

Early in 1990, I remember gazing in wonder at a giant model of the crystallized protease enzyme published by the NCI in 1989, with little sense of whether its therapeutic promise as a target was likelier to become science or science fiction. The first PI wouldn't be approved until late 1995. We'll never know whether a sensible, directed research approach -- if that isn't itself an oxymoron -- could have accelerated this discovery.

By summer 1994, TAG and allies such as David Barr and Derek Link at GMHC and activist Carlton Hogan from the University of Minnesota clinical trials coordinating center had come to believe that a new approach to AIDS clinical trials was necessary, one that allowed flexibility in the control arm (participants could take whatever approved or parallel-track HIV drug they wanted) but that restored rigor to the process by randomizing participants to receive a new PI or a placebo at a 2:1 ratio -- and that used clinical endpoints, notably time to an AIDS-defining event or death -- rather than relying on the discredited surrogate marker of CD4 cell-count changes due to therapy.

report covers

We then released our report, Rescuing Accelerated Approval: Moving Beyond the Status Quo, which was distributed at a contentious FDA advisory committee hearing in September 1994 (reviewed in "On a Darkling Plain" in the October 2012 TAGline).

TAG and our allies worked assiduously to watchdog the phase II/III clinical trials of every company that was making an HIV PI, including Abbott's ritonavir, Agouron's nelfinavir, Merck's indinavir, and Roche's saquinavir. TAG's recommendations to regulators and companies were published in the February 1995 report Problems with Protease Inhibitor Development Plans.

In summer 1995, Spencer Cox published his scathing, still-compelling report FDA Regulation of Anti-HIV Drugs: A Historical Perspective -- a cautionary retrospective on the first, mostly unsuccessful, ten years of HIV drug development and regulation.

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This article was provided by Treatment Action Group. It is a part of the publication TAGline.
 
See Also
Coverage of the 30th Anniversary of AIDS
20 Years of Magic: How One Man's HIV Disclosure Inspired Others
More on the History of the HIV/AIDS Epidemic

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