Treatment as Prevention: Do the Individual Prevention Benefits Translate to the Population Level?
- Cohen MS, Chen YQ, McCauley M, Gamble T, Hosseinipour MC, Kumarasamy N, et al. Prevention of HIV-1 infection with early antiretroviral therapy. New England Journal of Medicine. 2011 Aug 11;365(6):493-505.
- World Health Organization. WHO and U.S. NIH Working Group Meeting on Treatment for HIV Prevention among MSM: What Additional Evidence is Required. Geneva; 2011 Nov.
- UNAIDS. Report on the Global AIDS Epidemic. 2012.
- Hankins C. Overview of the current state of the epidemic. Current HIV/AIDS Reports. 2013 Jun;10(2):113-23.
- Tanser F, Bï¿½rnighausen T, Grapsa E, Zaidi J, Newell M-L. High coverage of ART associated with decline in risk of HIV acquisition in rural KwaZulu-Natal, South Africa. Science. 2013 Feb 22;339(6122):966-71.
- Montaner JSG, Lima VD, Barrios R, Yip B, Wood E, Kerr T, et al. Association of highly active antiretroviral therapy coverage, population viral load, and yearly new HIV diagnoses in British Columbia, Canada: a population-based study. Lancet. 2010 Aug 14;376(9740):532-9.
- Wood E, Kerr T, Marshall BDL, Li K, Zhang R, Hogg RS, et al. Longitudinal community plasma HIV-1 RNA concentrations and incidence of HIV-1 among injecting drug users: prospective cohort study. British Medical Journal. 2009;338:b1649.
- Wilson DP. HIV treatment as prevention: natural experiments highlight limits of antiretroviral treatment as HIV prevention. PLoS Medicine. 2012;9(7):e1001231.
- Beyrer C, Sullivan PS, Sanchez J, Dowdy D, Altman D, Trapence G, et al. A call to action for comprehensive HIV services for men who have sex with men. Lancet. 2012 Jul 28;380(9839):424-38.
- Sullivan PS, Carballo-Diéguez A, Coates T, Goodreau SM, McGowan I, Sanders EJ, et al. Successes and challenges of HIV prevention in men who have sex with men. Lancet. 2012 Jul 28;380(9839):388-99.
- Birrell PJ, Gill ON, Delpech VC, Brown AE, Desai S, Chadborn TR, et al. HIV incidence in men who have sex with men in England and Wales 2001-10: a nationwide population study. Lancet Infectious Diseases. 2013 Apr;13(4):313-8.
- Delpech V, Yin Z, Kall M, Brown A. The United Kingdom's National Health Service (NHS) provides excellent access to high quality HIV care: results from a national cohort. XIX International AIDS Conference. 2012 Jul 22;Abstract MOPDC0301.
- Supervie V, Costagliola D. The Spectrum of Engagement in HIV Care in France: Strengths and Gaps. 20th CROI Conference. 2013 Mar 3;Abstract 1030.
- Law MG, Woolley I, Templeton DJ, Roth N, Chuah J, Mulhall B, et al. Trends in detectable viral load by calendar year in the Australian HIV observational database. Journal of the International AIDS Society. 2011;14:10.
- Phillips AN, Cambiano V, Nakagawa F, Brown AE, Lampe F, Rodger A, et al. Increased HIV incidence in men who have sex with men despite high levels of ART-induced viral suppression: analysis of an extensively documented epidemic. PLoS ONE. 2013;8(2):e55312.
- Van Sighem A, Vidondo B, Glass TR, Bucher HC, Vernazza P, Gebhardt M, et al. Resurgence of HIV infection among men who have sex with men in Switzerland: mathematical modelling study. PLoS ONE. 2012;7(9):e44819.
- Van Sighem A, Jansen I, Bezemer D, De Wolf F, Prins M, Stolte I, et al. Increasing sexual risk behaviour among Dutch men who have sex with men: mathematical models versus prospective cohort data. AIDS. 2012 Sep 10;26(14):1840-3.
- Cowan SA, Gerstoft J, Haff J, Christiansen AH, Nielsen J, Obel N. Stable incidence of HIV diagnoses among Danish MSM despite increased engagement in unsafe sex. Journal of Acquired Immune Deficiency Syndromes. 2012 Sep 1;61(1):106-11.
- Das M, Chu PL, Santos G-M, Scheer S, Vittinghoff E, McFarland W, et al. Decreases in community viral load are accompanied by reductions in new HIV infections in San Francisco. PLoS ONE. 2010;5(6):e11068.
- Raymond HF, Chen Y-H, Ick T, Scheer S, Bernstein K, Liska S, et al. A new trend in the HIV epidemic among men who have sex with men, San Francisco, 2004-2011. Journal of Acquired Immune Deficiency Syndromes. 2013 Apr 15; 62(5):584-9).
- Castel AD, Befus M, Willis S, Griffin A, West T, Hader S, et al. Use of the community viral load as a population-based biomarker of HIV burden. AIDS. 2012 Jan 28;26(3):345-53.
- Krentz HB, Gill MJ. The Effect of Churn on Community Viral Load (CVL) in a well defined regional population. Journal of Acquired Immune Deficiency Syndromes. 2013 May. doi: 10.1097/QAI.0b013e31829cef18.
- Ramadanovic B, Vasarhelyi K, Nadaf A, Wittenberg RW, Montaner JSG, Wood E, et al. Changing Risk Behaviours and the HIV Epidemic: A Mathematical Analysis in the Context of Treatment as Prevention. PLoS ONE. 2013;8(5):e62321.
- Government of Canada PHA of C. HIV/AIDS Epi Updates -- July 2010 -- Public Health Agency of Canada [Internet]. [cited 2011 May 12]. Available from: http://www.phac-aspc.gc.ca/aids-sida/publication/epi/2010/2-eng.php
- Marks G, Crepaz N, Senterfitt JW, Janssen RS. Meta-analysis of high-risk sexual behavior in persons aware and unaware they are infected with HIV in the United States: implications for HIV prevention programs. Journal of Acquired Immune Deficiency Syndromes. 2005 Aug 1;39(4):446-53.
- Gardner EM, McLees MP, Steiner JF, del Rio C, Burman WJ. The Spectrum of Engagement in HIV Care and its Relevance to Test-and-Treat Strategies for Prevention of HIV Infection. Clinical Infectious Diseases. 2011 Mar 1;52(6):793-800.
- Siegfried N, Uthman OA, Rutherford GW. Optimal time for initiation of antiretroviral therapy in asymptomatic, HIV-infected, treatment-naive adults. Cochrane Database of Systematic Reviews Online. 2010;(3):CD008272.
- Sorensen SW, Sansom SL, Brooks JT, Marks G, Begier EM, Buchacz K, et al. A mathematical model of comprehensive test-and-treat services and HIV incidence among men who have sex with men in the United States. PLoS ONE. 2012;7(2):e29098.
- Charlebois ED, Das M, Porco TC, Havlir DV. The effect of expanded antiretroviral treatment strategies on the HIV epidemic among men who have sex with men in San Francisco. Clinical Infectious Diseases. 2011 Apr 15;52(8):1046-9.
- Walensky RP, Paltiel AD, Losina E, Morris BL, Scott CA, Rhode ER, et al. Test and treat DC: forecasting the impact of a comprehensive HIV strategy in Washington DC. Clinical Infectious Diseases. 2010 Aug 15;51(4):392-400.
- Sood N, Wagner Z, Jaycocks A, Drabo E, Vardavas R. Test-and-Treat in Los Angeles: A Mathematical Model of the Effects of Test-and-Treat for the Population of Men Who Have Sex With Men in Los Angeles County. Clinical Infectious Diseases. 2013 Jun;56(12):1789-96.
- Sandhu J, Chu T, Demlow E, MacDonald L, Heath K, Yip B, et al. Measuring the impact of enhanced testing and treatment on the HIV epidemic in Vancouver, Canada. Oral presentation at the 22nd Annual Canadian Conference on HIV/AIDS Research; Vancouver; 2013 Apr 11-14.
James Wilton is the coordinator of the Biomedical Science of HIV Prevention Project at CATIE. James is currently completing his master's degree of Public Health in Epidemiology at the University of Toronto and has completed an undergraduate degree in microbiology and immunology at the University of British Columbia.
Logan Broeckaert holds a Master's degree in History and is currently a researcher/writer at CATIE. Before joining CATIE, Logan worked on provincial and national research and knowledge exchange projects for the Canadian AIDS Society and the Ontario Public Health Association.
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