Isabelle Hodes,Weeds (2005-2012)
Isabelle (Allie Grant) on Weeds was often being berated by her conservative mother, Celia Hodes. Though she is very young at the beginning of the series, she openly claims to be a lesbian. Besides her sexuality, her mother is also frustrated that she doesn't conform to feminine gender norms and is overweight. This is exacerbated when Isabelle becomes the spokesperson for overweight children's clothing line "Huskaroo's." Isabelle is often shown as being the smartest and most capable of her entire family. Her mother Celia is overbearing and often unsure of herself and her father, Dean, is often seen as lacking nerve. She, however, is very smart and has a sharp wit. At the end of season 5, when her mother decides to start selling weed, she is deemed the "brains" of the operation.
Though Isabelle's sexuality is played up for comedy most of the time, she does have a few poignant moments in the series. Isabelle becomes best friends with Shane Botwin, the son of the series' protagonist, Nancy Botwin. They bond over their inept mothers. When Shane is in puberty, he asks to feel Isabelle's breasts, and she acquiesces, though she has no desire to touch him. In the series finale, her father reveals that she has had a sex change and is now Bruce Hodes.