NIH Scientists, Grantees Map Possible Path to an HIV Vaccine
Co-Evolution of HIV and Strong Antibody Response Charted for First Time
April 3, 2013
In an advance for HIV vaccine research, scientists have for the first time determined how both the virus and a resulting strong antibody response co-evolved in one HIV-infected individual. The findings could help researchers identify which proteins to use in investigational vaccines to induce antibodies capable of preventing infection from an array of HIV strains. Previously, a study of antibody genetics enabled scientists to deduce the step-by-step evolution of certain broadly neutralizing antibodies -- those that can prevent infection by the majority of HIV strains found around the globe. Yet the specific viruses that gave rise to those antibodies and the virus mutations that drove them to reach their final form remained unknown, hampering HIV vaccine discovery.View Full Article
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