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International News

HIV Associated With Nonresponse to HBV Vaccine

February 8, 2013

Researchers from the University of Washington and Kenyatta National Hospital in Nairobi, Kenya, conducted a prospective interventional study to investigate the response of adults with HIV to hepatitis B virus (HBV) vaccination. The 603 participants were members of the partners' pre-exposure prophylaxis (PrEP) study, and 310 of them had HIV infection. Participants were screened for HBV, and those who were found to be susceptible received HBV vaccine.

Six months after receiving the vaccine, 111 of the participants (35.8 percent) with HIV infection did not have protective HBV surface antibody titers compared to 42 (14.3 percent) of the 293 patients without HIV. A multivariate analysis of the participants with HIV indicated that sex and

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