Steep Fall in Incidence of TB Among HIV-Positive Heterosexuals in the UK
January 15, 2013
Investigators in the United Kingdom (UK) studied three national databases to determine the incidence of TB among HIV-infected heterosexuals living in England and Wales from 2002 to 2010. Results based on these databases show that, throughout this time period, incidence of TB decreased from 30 per 100 individuals to 8.8 per 1,000 individuals. The databases indicated that 45,322 heterosexuals received treatment for HIV infection in England and Wales; 4,266 of these individuals also were diagnosed with active TB. More than half of the individuals (54 percent) received an initial simultaneous diagnosis of HIV and TB, while 38 percent were diagnosed with TB more than three months after their HIV diagnosis. Almost all of the simultaneous diagnosis patients (92 percent) were diagnosed late with HIV and 53 percent had a CD4 cell count lower than 100 cells per cubic millimeter.
The TB incidence among HIV-infected heterosexuals was significantly higher than in the general UK population (0.14 per 1,000 individuals). Incidence of TB among HIV-infected black Africans (11 per 1,000 individuals) was approximately four times higher than the UK rate for HIV-negative Africans born abroad (2.7 per 1,000 individuals) and 25 times higher than the rate among HIV-negative black Africans born in the UK (0.43 per 1,000 individuals). The incidence of TB among HIV-positive persons not taking ART was more than 14 times higher than those on ART (56 per 1,000 individuals versus 3.9 per 1,000 individuals). The highest TB incidence for the study period was among persons not taking ART, who had a CD4 cell count below 200 cells per cubic millimeter .
01.15.2013; Michael Carter
This article was provided by U.S. Centers for Disease Control and Prevention. It is a part of the publication CDC HIV/Hepatitis/STD/TB Prevention News Update. Visit the CDC's website to find out more about their activities, publications and services.
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