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PEPFAR Blueprint: Creating an AIDS-Free Generation -- A Fact Sheet

November 29, 2012

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"The goal of an AIDS-free generation may be ambitious, but it is possible with the knowledge and interventions we have right now. And that is something we've never been able to say without qualification before. Imagine what the world will look like when we succeed."

-- U.S. Secretary of State Hillary Rodham Clinton, November 8, 2011


On November 8, 2011, Secretary Clinton declared that, for the first time in history, the world is at the point where an AIDS-free generation is in sight. And at the July 2012 International AIDS Conference, the Secretary called on the President's Emergency Plan for AIDS Relief (PEPFAR) to produce a blueprint outlining how the United States will contribute to reaching this goal.

Secretary Clinton defined an AIDS-free generation as one where virtually no children are born with HIV; where, as these children become teenagers and adults, they are at far lower risk of becoming infected than they would be today; and where those who do acquire HIV have access to treatment that helps prevent them from developing AIDS and passing the virus on to others. Creating an AIDS-free generation is an ambitious, but reachable, goal -- and now a policy imperative of the United States.


The PEPFAR Blueprint: Creating an AIDS-Free Generation reflects lessons learned from almost ten years of experience in supporting countries to rapidly scale-up HIV prevention, treatment and care services. It demonstrates the opportunity for the world to help move more countries toward and beyond the tipping point in their epidemics and put them on a path to achieving an AIDS-free generation. The blueprint makes clear that the United States' commitment to this goal will remain strong, comprehensive and driven by science. It clearly outlines what PEPFAR is doing, and will continue to do, to help make it a reality.

The blueprint also emphasizes that it will take a shared responsibility to create an AIDS-free generation. The United States leads the world in contributions in the fight against AIDS, having invested over $37 billion to date in bilateral funding and over $7 billion in the Global Fund to Fight AIDS, Tuberculosis and Malaria. However, the United States alone cannot achieve an AIDS-free generation. It requires the commitment of partner countries, reinforced with support from donor nations, civil society, people living with HIV, faith-based organizations, the private sector, foundations and multilateral institutions. It means investing in the principle of country ownership -- the end state in which partner countries lead, manage, coordinate and over time increasingly finance the efforts needed to achieve an AIDS-free generation in order to ensure that the AIDS response is effective, efficient and durable.

PEFFAR Blueprint: Creating an AIDS-Free Generation


Scientific advances and their successful implementation have brought the world to a tipping point in the fight against AIDS. The United States believes that by making smart investments based on sound science and a shared global responsibility, we can save millions of lives and achieve an AIDS-free generation.

PEPFAR's Principles for the Blueprint

To fulfill this vision, PEPFAR has based its blueprint on the following principles:

  • Make strategic, scientifically sound investments to rapidly scale-up core HIV prevention, treatment and care interventions and maximize impact.
  • Work with partner countries, donor nations, civil society, people living with HIV, faith-based organizations, the private sector, foundations and multilateral institutions to effectively mobilize, coordinate and efficiently utilize resources to expand high-impact strategies, saving more lives sooner.
  • Focus on women and girls to increase gender equality in HIV services.
  • End stigma and discrimination against people living with HIV and key populations, improving their access to, and uptake of, comprehensive HIV services.
  • Set benchmarks for outcomes and programmatic efficiencies through regularly assessed planning and reporting processes to ensure goals are being met.

These principles drive all of PEPFAR's work and are the foundation for the road maps that comprise the blueprint. Each road map -- the Road Map for Saving Lives; the Road Map for Smart Investments; the Road Map for Shared Responsibility; and the Road Map for Driving Results with Science -- contains specific goals and comprehensive action and implementation steps on how PEPFAR will support partner countries' efforts to meet these goals.

Road Map for Saving Lives

This road map addresses Secretary Clinton's call in her November 8, 2011 speech to scale-up combination HIV prevention and treatment interventions to save more lives.

Specifically, this road map outlines PEPFAR's plan to:

  1. Work toward the elimination of new HIV infections among children by 2015 and keeping their mothers alive.
  2. Increase coverage of HIV treatment both to reduce AIDS-related mortality and to enhance HIV prevention.
  3. Increase the number of males who are circumcised for HIV prevention.
  4. Increase access to, and uptake of, HIV testing and counseling, condoms and other evidence-based, appropriately-targeted prevention interventions.

Through its continued support for scale-up of combination prevention and treatment interventions in high-burden countries, PEPFAR will help countries reduce new HIV infections and decrease AIDS-related mortality, while simultaneously increasing the capacity of countries to sustain and support these efforts over time. This support will, in turn, move more countries past the programmatic tipping point in their HIV epidemics -- the point at which the annual increase in new patients on antiretroviral treatment (ART) exceeds annual new HIV infections -- and put them on the path toward achieving an AIDS-free generation.

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This article was provided by U.S. Department of State.
See Also
More News and Reports on U.S. Global HIV/AIDS Relief (PEPFAR)

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