PEPFAR Blueprint: Creating an AIDS-Free Generation -- A Fact Sheet

Road Map for Smart Investments

To achieve an AIDS-free generation, countries must target efforts where the virus is -- reaching and supporting those populations at greatest risk and urgently needing services. Accordingly, PEPFAR will work with countries to scale-up activities that have a strong evidence base to produce a population-level impact. PEPFAR will not support interventions that fail to target the epidemic. Concurrently, PEPFAR will work to realize efficiency gains to deliver greater results for its investments. PEPFAR has vastly increased value for money in its investments by reducing the costs of antiretroviral drugs (ARVs), streamlining supply chains, and working with partner countries to increase their investments.

PEPFAR will also continue to lead efforts to strengthen the Global Fund, which leverages U.S. contributions with contributions from other donors. This road map outlines how PEPFAR will follow the epidemic, invest in evidence-based interventions, and continue to generate greater value for money in its investments.

Specifically, this road map outlines PEPFAR's plan to:

1. Target HIV-associated tuberculosis (TB) and reduce co-morbidity and mortality.
2. Increase access to, and uptake of, HIV services by key populations.
3. Partner with people living with HIV to design, manage and implement HIV programs to ensure that they are responsive to, and respectful of, their needs.
4. Strengthen PEPFAR's continued focus on women, girls and gender equality.
5. Reach orphans and vulnerable children (OVC) affected by AIDS, and support programs that help them develop to their full potential.
6. Strengthen programmatic commitment to and emphasis on reaching and supporting young people with HIV services.
7. Strengthen PEPFAR supply chains and business processes to increase the efficiency of our investments.
8. Increase efficiencies through innovation and greater integrations of services with other U.S., bilateral and multilateral global health investments.

Road Map for Shared Responsibility

The goal of creating an AIDS-free generation is a shared responsibility with partner countries in a convening role. Neither the United States nor any other single entity cannot accomplish this goal alone. Rather, it requires a country to demonstrate political will and effective coordination of multiple partners that finance and carry out interventions both inside and outside of the health sector, and most importantly, meaningfully involve those living with and affected by HIV in all aspects of the response.

Specifically, this road map outlines PEPFAR's plan to:

1. Partner with countries in a joint move toward country-led, managed and implemented responses.
2. Increase support for civil society as a partner in the global AIDS response.
3. Expand collaboration with multilateral and bilateral partners.
4. Increase private sector mobilization toward an AIDS-free generation.

Road Map for Driving Results With Science

Scientific advances have brought the world to the point where calling for an AIDS-free generation is possible. And it is science that will underpin all PEPFAR efforts to help achieve this goal and save even more lives. To deliver the greatest response, PEPFAR will continue to support programs guided by scientific evidence. PEPFAR will go to where the science leads, translating science into program impact.

Specifically, this road map outlines PEPFAR's plan to:

1. Leverage greatest impact by continuing to invest in implementation science.
2. Support implementation research.
3. Evaluate the efficacy of optimized combination prevention.
4. Support innovative research to develop new technologies for prevention (e.g., microbicides, vaccines) and care (e.g., new treatments or treatment regimens).
5. Develop evidence-based approaches to reaching people early enough in their disease progression to help maintain a strong immune system; stave off opportunistic infections, particularly TB; and reduce new HIV infections.
6. Support the deployment of suitable technology for measurement of viral load, both through tiered laboratory networks and 'point-of-care' tests as they become available.
7. Assist countries in adopting breakthrough new technologies with proven impact, such as new, molecular-based TB tests that have dramatically reduced diagnosis and treatment time for people living with TB and HIV.