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An Overview of Stribild (Elvitegravir/Cobicistat/FTC/Tenofovir)

November 30, 2012

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Brand Name: Stribild
Other Names: QUAD, elvitegravir/GS-9350/emtricitabine/tenofovir disoproxil fumarate
Drug Class: Combination Drugs
Approved Use: Treatment of HIV Infection

WARNING:

Stribild can cause serious, life-threatening side effects. These include lactic acidosis (buildup of acid in the blood) and liver problems.

Contact your health care provider right away if you have any of the following symptoms that may signal lactic acidosis:

  • Weakness or tiredness.
  • Unusual (not normal) muscle pain.
  • Trouble breathing.
  • Stomach pain with nausea and vomiting.
  • Feeling cold, especially in your arms and legs.
  • Dizziness or lightheadedness.
  • Fast or irregular heartbeat.

Contact your health care provider right away if you have any of the following symptoms that may signal liver problems:

  • Yellowing of your skin or the whites of your eyes (jaundice).
  • Dark-colored urine.
  • Light-colored bowel movements.
  • Loss of appetite for several days or longer.
  • Nausea.
  • Pain in the stomach area (abdominal pain).

Stribild is not approved for the treatment of hepatitis B virus (HBV) infection. People co-infected with HIV and HBV who stopped taking emtricitabine or tenofovir disoproxil fumarate, which are two anti-HIV medicines included in Stribild, have had severe worsening of their HBV infections. The HBV drug adefovir dipivoxil (brand name: Hepsera) should not be taken with Stribild.

While taking Stribild, it is important to keep all of your appointments with your health care provider.


What is Stribild?

Stribild is a prescription medicine approved by the U.S. Food and Drug Administration (FDA) for the treatment of HIV infection in adults who have never taken HIV medicines before. Stribild is a complete regimen for the treatment of HIV infection and should not be used in combination with other anti-HIV medicines.

Stribild contains the following four medicines combined in one pill: elvitegravir, cobicistat, emtricitabine, and tenofovir disoproxil fumarate. Elvitegravir is a type of anti-HIV medicine called an integrase inhibitor. Cobicistat is a type of medicine called a pharmacokinetic enhancer. It is used to increase the effectiveness of elvitegravir. Emtricitabine and tenofovir disoproxil fumarate are types of anti-HIV medicines called nucleoside reverse transcriptase inhibitors (NRTIs). The four drugs in combination prevent HIV from replicating and lower the amount of HIV in the blood.

Stribild does not cure HIV/AIDS. It is not known if Stribild reduces the risk of passing HIV to other people.


What should I tell my health care provider before taking Stribild?

Before taking Stribild, tell your health care provider:

  • If you have liver problems, including HBV infection.
  • If you have kidney problems.
  • If you have bone problems.
  • If you have any other medical conditions.
  • If you are pregnant or plan to become pregnant. Whether Stribild can harm an unborn baby is unknown.
  • If you are breastfeeding or plan to breastfeed. Do not breastfeed if you are infected with HIV or are taking Stribild.
  • About other prescription and nonprescription medicines, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Stribild may affect the way other medicines or products work, and other medicines or products may affect how Stribild works. Taking Stribild together with certain medicines or products may cause serious side effects.
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This article was provided by AIDSinfo. Visit the AIDSinfo website to find out more about their activities and publications.
 
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