July 25, 2012
My sixth full day of conferencing was a long one ... 16 hours from Breakfast Update through Networking Reception. I'll highlight the day's early and late sessions.
Tuesday's plenary session was "Challenges and Solutions." In "Viral Eradication: The Cure Agenda," Javier Martinez-Picado talked about the need for a cure, barriers to a cure, strategies to a cure, priority areas for research, scientific and technical challenges, and other considerations. He stressed that tissue is a greater source of plasma viremia than the blood. The increased HIV burden in tissues may be the result of different drug penetration, cell-to-cell transmission, or some other unknown factor.
Former Senator, Dr. Bill Frist, introduced Dr. Nelly Mugo from Kenya who presented "Implementation Science." She led with a shocker. Kenya has had 30 million AIDS-related deaths since 1980, and the entire population of Kenya is 40 million people. She listed three needs:
Dr. Mugo stressed that PrEP, like ART, works when taken as directed, but risk perception is key for any strategy to be effective. She also was adamant that PrEP is not a lifelong intervention. It is to be used "for a season." In Kenya, 20% of PLHIV refused treatment primarily because they felt well. Medical professionals have little experience starting ART in asymptomatic persons. Adherence, sexual risk taking, ARV resistance, who will use, and who will pay are all challenges and opportunities shared by ARV and PrEP.
"What Will It Take to Turn the Tide?" was presented by Dr. Bernhard Schwartlander. He left is with a few gems:
He also reviewed various options for domestic HIV financing in Africa as well as options for global development financing. Finally, Dr. Howard Koh from HHS highlighted the administration's efforts, successes, and plans for the National HIV/AIDS Strategy in his presentation "Building on Success: A National Strategy to Save Lives."
The Lancet medical journal closed out the day with its "Special Theme Series: Men Who Have Sex With Men and HIV." Among the first issues highlighted was that homophobia is the key driver of the increasing HIV epidemic among MSM. Young men are still dying, not because there isn't any treatment but because of stigma and discrimination.
The efficiency of transmission of HIV is increased in MSM who practice versatility in being insertive and receptive during anal sex. Due to the biology of HIV in anal sex, even substantial behavior change is not enough to change the epidemic.
In discussing "Successes and Challenges," Patrick Sullivan suggested that using the HIV prevention technologies we have today, we can prevent 75% of new HIV infections among MSM. He kept with a popular conference theme in saying that combination prevention (behavior, biomedical, barrier, structural, social, and societal interventions) will be required to have any significant impact on the epidemic. According to Sullivan, condoms reduce transmission by 80%, PrEP reduces transmission by 44%, HIV testing reduces transmission by 68%, and treatment reduces transmission by 96%. Those interventions along with changing behaviors, decreasing stigma, and ending criminalization equal combination prevention.
Ken Mayer (again?!?!) presented "Caring for the Whole Person." He talked about the effects of stigma and the need for comprehensive care. Although black MSM do not have higher risk behaviors than other groups, they tend to meet partners in high prevalence pools (other black MSM), which increases their risk of HIV infection. Safer sex, according to Dr. Mayer, is not just the absence of disease, but also a safe and pleasurable experience.
Dennis Altman went deeper into the issue of "Stigma and Discrimination." Just because homosexuality is not criminalized in the U.S., states can still persecute homosexuals. Legal change is important but not sufficient. He goes on to explain that the roots of homophobia stem from such various sources as religion, traditional gender power relations, and "political homophobia."
Gift Trapence from Malawi provided some historical perspective of the earliest responses to HIV by gay men in his presentation "From Personal Survival to Public Health: Gay and MSM Community Leadership in the HIV Response."
Greg Millet provided some interesting data in "HIV-related Disparities Among Black MSM and Associations With Structural Factors." Comparing black MSM to other MSM in the U.S. and U.K., even with comparable risk behavior, black men are three times more likely to be HIV-positive, 50% less likely to be on ART, 50% less likely to adhere to ART, and 50% less likely to have health insurance. Will newer biomedical interventions even be available/accessible to black MSM?
Black MSM in the U.S. are 8.5 times more likely to be HIV-positive than black populations worldwide and 15 times more likely to be HIV-positive than general populations. Risk behavior does not explain these HIV disparities. HIV criminalization is responsible for a two-fold increase in HIV infection in Caribbean and African MSM.
Chris Collins from AmFar ended the session with a "Call to Action for Comprehensive HIV Services for Men Who Have Sex With Men." Guess what he highlighted? Combination prevention! MSM need access to testing, treatment, condoms and lubricants, mental health, substance abuse interventions, and trained providers.
As if the 12-hour day wasn't enough, I headed down to the Global Village for Cornelius Jones' 7pm performance of excerpts from his one-man show "Shadows and Lights" [http://youtu.be/iSgRMUz1cHk]. I'm really glad I did. That brotha is talented... and deep.
Tomorrow is the day for Combination Prevention. After today, I hope I last ...
Robert Newells is the founder of Healing Faith, the HIV prevention program of the Life Care Ministry at Imani Community Church in Oakland, Calif. Rob works intentionally with and through African-American faith communities to reduce stigma and provide culturally relevant HIV information to all Oakland residents.