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International News

United Kingdom: Positive Results for HIV Drug Study

July 16, 2012

A once-daily triple-drug HIV regimen containing an experimental integrase inhibitor performed better in suppressing the virus than Atripla in a Phase III trial, developers of the new drug say. The trial pitted dolutegravir in combination with two older HIV drugs against the three-drug Atripla.

Results from the SINGLE trial found 88 percent of patients taking the dolutegravir-based regimen achieved undetectable virus at 48 weeks, compared with 81 percent for Atripla patients. Dolutegravir is being developed by Japanese partner Shionogi & Co. and ViiV Healthcare, a partnership of UK-based GlaxoSmithKline and US-based Pfizer.

Complete trial results will be presented at an upcoming scientific meeting. In April, the first set of study results showed dolutegravir was as effective as twice-daily Isentress. Four Phase III studies due for reporting this year are designed to accompany regulatory filings in support of the drug.

Dolutegravir's low-milligram dosing could make it easier to include in a fixed-dose combination pill, and there could be fewer side effects because a booster is not required.

Back to other news for July 2012

Adapted from:
Wall Street Journal
07.11.2012; Sten Stovall

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This article was provided by CDC National Prevention Information Network. It is a part of the publication CDC HIV/Hepatitis/STD/TB Prevention News Update.
See Also
More on HIV Medications
Other Integrase Inhibitors

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