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What's New in the U.S. HHS Antiretroviral Therapy Guidelines for Adults and Adolescents

April 8, 2015

Revisions to the May 1, 2014, version of the guidelines include key updates to several existing sections and the addition of two new tables. Significant updates are highlighted throughout the document.

Key Updates

The following are key updates to existing sections of the guidelines.

What to Start: Initial Combination Regimens for the Antiretroviral-Naive Patient

Since the last version of these guidelines, data from clinical trials and cohort studies, as well as experience in clinical practice, have prompted significant changes to the list of Recommended, Alternative, and Other regimens for treatment-naive patients (Table 6). Additionally, a new table, titled "Antiretroviral (ARV) Regimen Considerations as Initial Therapy Based on Specific Clinical Scenarios," has been created to guide clinicians on the selection of an initial ARV regimen based on specific clinical scenarios and ARV-related considerations (Table 7).

Virologic Failure

The following key updates have been made to this section:

Poor CD4 Cell Recovery and Persistent Inflammation Despite Viral Suppression

Acute/Early HIV Infection

HIV-2 Infection

HIV/Hepatitis C Virus (HCV) Coinfection

Drug Interaction

Additional Updates

Minor revisions have also been made to the following sections:

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