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Medical News

HIV Trial Scrapped After Gel Found to Be Ineffective

November 29, 2011

A routine review of data from a large clinical trial found that a tenofovir-based vaginal gel was not effective in preventing HIV in women, researchers reported Friday.

Since the review found no safety concerns with the gel, women in the vaginal gel arms of the VOICE (Vaginal and Oral Interventions to Control the Epidemic) study will be told to discontinue its use at their next regularly scheduled clinic visit, the Microbicides Trial Network said.

In 2010, the CAPRISA (Center for the AIDS Program of Research in South Africa) study in South Africa found a tenofovir-based microbicide vaginal gel was 39 percent more effective than placebo gel when used before and after sex. In regular users, it was 54 percent effective. The VOICE study, begun in 2009 with 5,029 sexually active HIV-negative women in South Africa, Uganda, and Zimbabwe, was expected to back those findings. Instead, the interim data review found no difference between the

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