Saul Holden (Ron Rifkin) -- Brothers & Sisters (ABC, 2006-2011)
They don't call it "May Sweeps" for nothing. When the fourth season of ABC's now-defunct Brothers & Sisters ended, we were given a shocker: Uncle Saul (played by veteran actor Ron Rifkin) was diagnosed with HIV after unknowingly living with the virus for over 20 years. Only after a huge car crash did he admit to his family that he was positive. During the fifth and final season, we saw Saul struggle with coming to terms with his diagnosis and navigating the dating game. This storyline was definitely needed -- we hadn't had an HIV-positive series regular on primetime TV for five years.