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Case Reports: Cushing's Syndrome With Atazanavir/Ritonavir

July/August 2011

Two cases have been reported recently of patients developing Cushing's syndrome when treated with atazanavir/ritonavir and corticosteroids.

The first case describes a 75 year old man with a history of HIV for 27 years, hepatitis C, hypothyroidism, recurrent deep venous thrombosis, hypertension, and chronic kidney disease was admitted for treatment of worsening chronic diarrhea and bright red blood per rectum.1

His antiretroviral regimen was atazanavir/ritonavir (300/100 mg daily), lamivudine (150 mg daily) and nevirapine (300 mg twice daily). Other medications included atenolol, atropine/diphenoxylate, calcitriol, cholecalciferol, fondaparinux, levothyroxine, lisinopril, loperamide, ranitidine, testosterone patch, trazodone, and vardenafil. Colonoscopy showed lymphocytic colitis at multiple biopsy sites and oral budesonide (3 mg 3 times a day) was started.

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See Also
More on HIV Medications
More News and Research on Atazanavir (Reyataz)

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