An Overview of Complera (Rilpivirine/Tenofovir/Emtricitabine)
January 19, 2017
Brand Name: Complera
Complera can cause serious, life-threatening side effects. These include lactic acidosis (buildup of acid in the blood) and liver problems.
Contact your health care provider right away if you have any of the following symptoms that may signal lactic acidosis:
Stop taking Complera and contact your health care provider right away if you get a rash with any of the following symptoms:
Liver problems have occurred even in a few people who had no prior risk factors for liver problems. People taking Complera should be monitored for liver problems before starting treatment and during treatment. Contact your health care provider right away if you have any of the following symptoms that could be signs of liver problems:
Complera is not approved for the treatment of hepatitis B virus (HBV) infection. If you have both HIV and HBV infection and take Complera, your HBV infection may get worse (flare up) if you stop taking Complera.
Complera should not be taken with certain drugs, including the HBV drug adefovir dipivoxil (brand name: Hepsera) and any drugs that contain emtricitabine, rilpivirine, tenofovir disproxil fumarate, or lamivudine.
While taking Complera, it is important to keep all of your appointments with your health care provider.
What Is Complera?
Complera is a prescription medicine approved by the U.S. Food and Drug Administration (FDA) for the treatment of HIV infection in adults and children 12 years of age and older who have never taken HIV medicines before and who have a viral load (number of HIV RNA copies per mL of blood) of 100,000 copies/mL or less. In certain people who have a viral load of less than 50 copies/mL and who are on a stable HIV medicine regimen, Complera may be used to replace their current HIV medicine regimen. Complera is a complete regimen for the treatment of HIV infection and should not be used with other HIV medicines.
Complera contains the following three different medicines combined in one pill:
Both NNRTIs and NRTIs block an HIV enzyme called reverse transcriptase. (An enzyme is a protein that starts or increases the speed of a chemical reaction.) By blocking reverse transcriptase, the three drugs in combination prevent HIV from multiplying and can reduce the amount of HIV in the body.
HIV medicines can't cure HIV/AIDS, but taking a combination of HIV medicines (called an HIV regimen) every day helps people with HIV live longer, healthier lives. HIV medicines also reduce the risk of HIV transmission.
What Should I Tell My Health Care Provider Before Taking Complera?
Before taking Complera, tell your health care provider:
How Should I Take Complera?
Complera comes in tablet form. Each tablet contains:
Take Complera according to your health care provider's instructions.
Take Complera with food (a protein drink is not a substitute for food). Do not take Complera with other HIV medicines. (Sometimes an additional tablet of rilpivirine is given with Complera.)
If you take too much Complera, contact your health care provider or local poison control center (1-800-222-1222) right away, or go to the nearest hospital emergency room.
For more information on how to take Complera, see the FDA drug label from DailyMed. (DailyMed is a federal website that includes the most recent drug labels submitted to FDA.)
This article was provided by AIDSinfo. Visit the AIDSinfo website to find out more about their activities and publications.
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