Women, Hormones and HIV
October 24, 2015
Women who have low estrogen levels may choose to replace the estrogen in order to regulate menstrual periods and help relieve pre-menstrual syndrome (PMS). However, the most common reason to replace estrogen is to relieve the symptoms of menopause.
Care must be taken in replacing estrogen. Taking estrogen without progesterone increases the risk of uterine cancer. If a woman's uterus (womb) has been removed, she can take estrogen by itself. This is called estrogen replacement therapy or ERT.
Women who still have a uterus usually take a combination of estrogen and progesterone. This is called hormone replacement therapy (HRT).
Although HRT used to be regularly recommended to relieve menopausal symptoms and reduce bone loss, long-term use of HRT is now questionable. Research has shown that HRT can increase women's risk for breast cancer, heart disease, and stroke. HRT may be appropriate for a short time to relieve menopausal symptoms that do not respond to other therapies. Estrogen and progesterone are available in patches, creams, and vaginal rings; these may be an alternative to the pill form of HRT and may not carry the same risks.
To figure out if HRT is right for you, speak with your health care provider about all the risks and benefits. When deciding about HRT, it is important to tell your provider about any drugs or other treatments you are taking. HIV drugs can sometimes reduce the effectiveness of hormones, including birth control pills containing estrogen and progesterone. Estrogen can also cause decreased levels of HIV drugs and put you at risk for a rising viral load and HIV drug resistance.
There are other therapies available to treat menopausal symptoms. However, these may also have unwanted side effects or interact with HIV drugs. In addition, some may not have adequate scientific evidence demonstrating their effectiveness. If you choose alternative therapies it is best to consult a skilled practitioner and let your regular health care provider know exactly what you are doing.
Other treatments may include:
- Traditional Chinese Medicine (e.g., acupuncture, Chinese herbs)
- Herbal or botanical supplements (e.g., black cohosh, soy, red clover, dong quai, kava, ginseng)
- Antidepressant drugs and/or counseling
- Prescription drugs to prevent bone loss (e.g., Fosamax, Actonel, or Boniva)
- Mindfulness training
Shortages of testosterone can result in fatigue, sexual problems, depression, and muscle loss. Many women who take testosterone or anabolic steroids report improved energy, sex drive, mood, and better quality of life. Anabolic steroids are drugs with very similar effects as testosterone. They have also been shown to increase lean muscle mass and add weight.
Speak to your health care provider about possible side effects from testosterone use. Women may experience facial hair growth, deepening of their voice, or clitoral enlargement. Testosterone is available in many forms; patches, gels, and creams may be preferred to injections and tablets because they decrease the likelihood of side effects listed above. Testosterone is not recommended for women who are pregnant or who wish to become pregnant.
Women suffering from weight loss (wasting) or lipodystrophy may consider treatment with human growth hormone (HGH, Serostim). HGH has been shown to increase lean muscle mass and may reduce fat changes associated with lipodystrophy. Unfortunately, HGH does not seem to correct facial wasting. Because of its high cost and potential side effects (e.g., high cholesterol, muscle and joint pain, swelling due to fluid retention), HGH is not for everyone.
Discuss any symptoms you are experiencing with your health care provider. If a hormone imbalance is found to be the cause, you can explore treatment options. Also make sure to discuss drug interactions and long-term side effects of hormone use.
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