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Hepatitis C

April 24, 2014

What Is Hepatitis C?

The hepatitis C virus (HCV) can cause liver damage. Hepatitis C is transmitted primarily by direct blood-to-blood contact. Most people get HCV through injection drug use with shared equipment. Up to 90% of people who have ever injected drugs, even just once, have been infected with HCV. Some people have gotten HCV from unprotected sex. This is particularly true for HIV-positive men who have sex with men, people with other sexually transmitted diseases, people with multiple sexual partners, and those who engage in sexual activities that cause bleeding, such as fisting. Tattooing with shared ink and equipment can cause infection. Some people get infected in medical settings, through unsterilized equipment. Healthcare workers can get HCV through needlestick accidents. The risk from blood transfusions and blood products in the US is virtually zero.

HCV spreads more easily than HIV through contact with infected blood. In the US, at least 4 times as many people have HCV as have HIV. You could be infected with HCV and not know it, since most people don't have symptoms. About 15% to 30% of people clear HCV from their bodies without treatment. The rest develop chronic infection, and the virus stays in their body unless it is successfully treated. HCV might not cause any problems for about 15 to 20 years, or even longer, but it can cause serious liver damage, called cirrhosis. People with cirrhosis are at risk for liver cancer, liver failure, and death. A large study in 2011 found that having chronic hepatitis C doubled the risk of death from any cause.

How Is It Diagnosed?

Some people with HCV have abnormally high levels of liver enzymes, and their doctor orders an HCV test. See Fact Sheet 122 for more information on these tests. If you have been at risk for HCV, get tested even if your liver enzyme levels are normal. HCV testing is recommended for all people with HIV, since having both viruses, called coinfection, is common.

Usually, the first blood test for HCV is an antibody test. A positive result means that you have been infected with HCV. However, some people recover from HCV without treatment, so you need a HCV viral load test to know if you have chronic infection. Hep C viral load testing is recommended if you have been at risk for HCV or have any signs or symptoms of hepatitis.

Hep C tests are similar to the HIV antibody test (see Fact Sheet 102) and viral load tests (see Fact Sheet 125). Unlike HIV viral loads, HCV viral loads are usually much higher; often in the millions. Unlike HIV, the HCV viral load does not predict disease progression.

Hep C viral load or liver enzyme levels cannot tell how damaged your liver is. A liver biopsy is the best way to check the condition of the liver. See Fact Sheet 672 for more information. If there is very little liver damage, some experts recommend monitoring; if there is damage (scarring), HCV treatment may be necessary.

How Is Hep C Treated?

Almost all cases of HCV could be cured if treatment with interferon was started very soon after infection. Unfortunately most people don't have any signs of hepatitis, or can mistake them for the flu. Most cases are not diagnosed until years later. In 2014 the World Health Organization issued its first HCV treatment guidelines. They are available at

The first step in treating HCV is to find out which genotype of HCV you have (see Fact Sheet 674). Most people with HCV in the US have genotype 1. Genotypes 1 and 4 are harder to treat than genotypes 2 or 3.

The usual treatment for HCV has been a combination of two drugs, pegylated interferon (pegIFN) and ribavirin (RBV). Fact Sheet 680 has more information on these two drugs. pegIFN is injected once a week. RBV is a pill taken twice daily. These drugs have some serious side effects, including flu-like symptoms, irritability, depression, and low red blood cell counts (anemia) or white blood cell counts (neutropenia). Talk with your health care provider about how to deal with side effects.

New treatments for HCV are being developed. At present, these drugs are added to pegIFN/RBV. See Fact Sheet 682 for more information on telaprevir (Incivek) and Fact Sheet 683 on boceprevir (Victrelis).

HCV treatment does not work for everyone, and some people can't tolerate the side effects. People do better if they:

Can Hep C Be Prevented?

Although there are vaccines to protect you from getting infected with Hep A or Hep B, there is no vaccine yet for Hep C. The best way to prevent Hep C infection is to avoid being exposed to blood that is infected with Hep C. If you don't share equipment to use drugs and avoid other contact with the blood of people infected with Hep C, your risk of Hep C infection will be lower.

Hep C and HIV Together

Because HIV and HCV are both spread by contact with infected blood, many people are "coinfected" with both viruses. HIV increases liver damage from HCV. Coinfected people are more likely to have liver problems from anti-HIV drugs, but your health care provider can choose drugs that easier on the liver.

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