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Information

An Overview of Cobicistat

October 13, 2014

Cobicistat

Brand Name: Tybost
Other Names: COBI
Drug Class: Pharmacokinetic Enhancers (CYP3A Inhibitors)
Approved Use: As a pharmacokinetic enhancer of atazanavir or darunavir (once daily dosing regimen), in combination with other antiretroviral agents in the treatment of HIV-1 infection
Company: Gilead Sciences, Inc.


Chemical Image

Cobicistat chemical image

cobicistat
Molecular Weight: 776.0347


WARNING:

Some drugs should not be taken with cobicistat. Cobicistat may interact with many drugs, which can cause serious, life-threatening side effects.

When taken with certain other medicines, cobicistat can cause new or worse kidney problems, including kidney failure. Your health care provider should check your kidneys before you start and while you are taking cobicistat.

If you are taking cobicistat, tell your health care provider about other prescription and nonprescription medicines, vitamins, nutritional supplements, and herbal products you are taking or plan to take.

While taking cobicistat, it is important to keep all of your appointments with your health care provider.


What Is Cobicistat?

Cobicistat is a prescription medicine approved by the U.S. Food and Drug Administration (FDA) for use in adults one time each day with the HIV medicines atazanavir (brand name:Reyataz) or darunavir (brand name: Prezista) to increase the amount of those medicines in the blood.

Cobicistat is a type of medicine called a pharmacokinetic enhancer. Pharmacokinetic enhancers are used in HIV treatment to increase the amount of other HIV medicines in the blood. When used with atazanavir (brand name: Reyataz) or darunavir (brand name: Prezista), cobicistat interferes with the breakdown of the drugs in the body. In this way, cobicistat increases the blood levels of atazanavir (brand name: Reyataz) or darunavir (brand name: Prezista), making them more effective.

Cobicistat is not an HIV medicine and does not treat HIV. Even if you take cobicistat and atazanavir (brand name: Reyataz) or darunavir (brand name: Prezista), you must also take all the HIV medicines prescribed by your health care provider.


What Should I Tell My Health Care Provider Before Taking Cobicistat?

Before taking cobicistat, tell your health care provider:

  • If you are allergic to cobicistat, atazanavir (brand name: Reyataz), darunavir (brand name: Prezista), or any other medicines.
  • If you have kidney problems.
  • If you have liver problems.
  • If you have any other medical conditions.
  • If you are pregnant or plan to become pregnant. Whether cobicistat can harm an unborn baby is unknown. Talk to your health care provider about possible risks with taking cobicistat when pregnant. Tell your healthcare provider if you become pregnant while taking cobicistat.
  • If you are breastfeeding or plan to breastfeed. Do not breastfeed if you are infected with HIV or are taking cobicistat.
  • If you are using hormone-based birth control (such as pills, patches, or rings.) Whether hormone-based birth control has any effects on cobicistat is unknown. Your health care provider can help you decide on the best birth control to use while you are taking cobicistat.
  • About other prescription and nonprescription medicines, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Cobicistat may affect the way other medicines or products work, and other medicines or products may affect how cobicistat works. Taking cobicistat together with certain medicines or products may cause serious and life-threatening side effects.
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How Should I Take Cobicistat?

Cobicistat (brand name: Tybost) comes in tablet form. Each tablet contains 150 mg of cobicistat.

Take cobicistat according to your health care provider's instructions.

Take cobicistat one time each day at the same time you take atazanavir (brand name: Reyataz) or darunavir (brand name: Prezista). It is important to take these medicines on a regular dosing schedule.

Take cobicistat with food.

If you take too much cobicistat, contact your health care provider or local poison control center (1-800-222-1222) right away, or go to the nearest hospital emergency room.

For more information on how to take cobicistat, see the FDA drug label from DailyMed. (DailyMed is a federal website that includes the most recent drug labels submitted to FDA.)


What Should I Do if I Forget a Dose?

If you miss a dose of cobicistat with atazanavir (brand name: Reyataz) or darunavir (brand name: Prezista) by less than 12 hours, take the missed dose of cobicistat with atazanavir or darunavir right away. Then take your next dose of cobicistat together with atazanavir or darunavir as usual. If you miss a dose of cobicistat with atazanavir or darunavir by more than 12 hours, wait and take the next dose at your usual time. If you miss a dose of cobicistat with atazanavir or darunavir, do not take two doses at the same time to make up for the missed dose.


What Side Effects Can Cobicistat Cause?

Some drugs should not be taken with cobicistat. Cobicistat may interact with many drugs, which can cause serious, life-threatening side effects. When taken with certain other medicines, cobicistat can cause new or worse kidney problems, including kidney failure. (See the WARNING above.)

The most common side effects of cobicistat with atazanavir (brand name: Reyataz) include yellowing of the skin or eyes (jaundice) and nausea.

Tell your health care provider if you have any side effect that bothers you or that does not go away.

These are not all the possible side effects of cobicistat. To learn more about possible side effects of cobicistat, read the drug label or package insert or talk to your health care provider or pharmacist.

You can also report side effects to FDA at 1-800-FDA-1088 (1-800-332-1088) or online at www.accessdata.fda.gov/scripts/medwatch/.


How Should Cobicistat Be Stored?

  • Store cobicistat at room temperature, 68°F to 77°F (20°C to 25°C).
  • Keep cobicistat in the container that it came in and keep the container tightly closed. Do not remove the small packet of drying agent (called a desiccant) from the container. The desiccant protects the cobicistat tablets from moisture.
  • Do not use cobicistat if the original seal over the bottle opening is broken or missing.
  • Follow FDA's guidelines to safely dispose of cobicistat that is no longer needed or expired (out of date).
  • Keep cobicistat and all medicines out of reach of children.


Where Can I Find More Information About Cobicistat?

More information about cobicistat is available:


Manufacturer Information

Gilead Sciences, Inc.
800-445-3235

The above Patient Version drug summary is based on the following FDA label(s): tablet (film coated).



  
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This article was provided by AIDSinfo. Visit the AIDSinfo website to find out more about their activities and publications.
 
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