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Information

HIV Drug Chart (Overview)

December 19, 2014

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Protease Inhibitors (PIs)

Aptivus

Brand Name: Aptivus
Other Name(s): TPV
Generic Name(s): Tipranavir
Class of Drug: PI
Common Side Effects: Nausea, vomiting, diarrhea, stomach pain, fatigue, headaches
Serious Side Effects: Liver problems, lipodystrophy, increased cholesterol and triglycerides, sulfa allergy, high blood sugar, internal bleeding, Stevens-Johnson syndrome (severe skin rash accompanied by fever, fatigue, muscle or joint aches, blisters, facial and tongue swelling)
Special Considerations: Should not be taken by people with moderate-to-severe hepatitis B or C
Pregnancy: No information in human pregnancy
Women-Specific Information: Because Aptivus reduces the levels of some hormonal contraceptives, talk to your health care provider about changing to or adding other methods of contraception if you take Aptivus. Skin rash is a more common side effect in women taking birth control pills or hormone replacement therapy.
Who Produces the Drug: Boehringer Ingelheim
Web Site for Drug Info: www.aptivus.com
Patient Assistance: Aptivus Patient Assistance Program or 1-800-556-8317

No co-payment assistance is available

Crixivan

Brand Name: Crixivan
Other Name(s): IDV
Generic Name(s): Indinavir
Class of Drug: PI
Common Side Effects: Nausea, vomiting, diarrhea, stomach pain, heartburn, headaches, fatigue, trouble sleeping, rash, dry or itchy skin, hair loss, back pain
Serious Side Effects: Kidney stones (drink eight glasses of water daily to lower risk of kidney stones), hemolytic anemia (destruction of red blood cells), lipodystrophy, increased cholesterol and triglycerides, high blood sugar, jaundice (yellowing of the skin and eyes), increased bleeding in people with hemophilia
Special Considerations: Do not take Crixivan with grapefruit juice
Pregnancy: No evidence of human birth defects. There is some concern about Crixivan's effect on infant liver health. Use of Crixivan without Norvir during pregnancy is not recommended.
Women-Specific Information: Some studies suggest that women taking Crixivan are more likely than men to develop kidney problems
Who Produces the Drug: Merck
Web Site for Drug Info: Crixivan
Patient Assistance: Merck SUPPORT Program (includes Crixivan)

1-800-850-3430

No co-payment assistance is available

Invirase

Brand Name: Invirase
Other Name(s): SQV
Generic Name(s): Saquinavir
Class of Drug: PI
Common Side Effects: Nausea, diarrhea, stomach pain, gas, headaches, fatigue, trouble sleeping, mental confusion
Serious Side Effects: Lipodystrophy, high blood sugar, increased cholesterol and triglycerides, increased bleeding in people with hemophilia, jaundice (yellowing of the skin and eyes), increased risk of developing abnormal heart rhythms
Special Considerations: Another version of this drug called Fortovase was discontinued in the US in 2006, but is still used in other countries. Invirase is the only version available in the US.
Pregnancy: No information in human pregnancy. Use of Invirase without Norvir during pregnancy is not recommended.
Women-Specific Information: Because Invirase reduces the levels of some hormonal contraceptives, talk to your health care provider about changing to or adding other methods of contraception if you take Invirase
Who Produces the Drug: Genentech (Roche)
Web Site for Drug Info: Invirase
Patient Assistance: Genentech Access Solutions

1-866-4ACCESS (1-866-422-2377)

Kaletra

Brand Name: Kaletra (Aluvia in some countries outside the US)
Other Name(s): LPV/r
Generic Name(s): Lopinavir plus ritonavir (combined in the same tablet)
Class of Drug: PI
Common Side Effects: Diarrhea, nausea, vomiting, stomach pain, headaches, fatigue, weakness, heartburn
Serious Side Effects: Liver problems, pancreatitis, lipodystrophy, increased cholesterol and triglycerides, high blood sugar, increased bleeding in people with hemophilia
Special Considerations:  
Pregnancy: No evidence of human birth defects. Evidence shows that Kaletra is safe in the short-term for mothers and infants. Once-daily dosing and oral solution containing alcohol are not recommended for use during pregnancy.
Women-Specific Information: Because Kaletra reduces the levels of some hormonal contraceptives, talk to your health care provider about changing to or adding other methods of contraception if you take Kaletra
Who Produces the Drug: AbbVie
Web Site for Drug Info: Kaletra
Patient Assistance: Kaletra patient assistance 

1-800-222-6885 

Copay savings card

Lexiva

Brand Name: Lexiva (Telzir in some countries)
Other Name(s): FPV
Generic Name(s): Fosamprenavir
Class of Drug: PI
Common Side Effects: Nausea, vomiting, diarrhea, stomach pain, gas, headaches, rash, numbness or tingling around the mouth
Serious Side Effects: Kidney stones (drink eight glasses of water daily to lower risk of kidney stones), lipodystrophy, increased cholesterol and triglycerides, liver problems, sulfa allergy, Stevens-Johnson syndrome (severe skin rash accompanied by fever, fatigue, muscle or joint aches, blisters, facial and tongue swelling), increased bleeding in people with hemophilia, high blood sugar, hemolytic anemia (destruction of red blood cells)
Special Considerations: Triglyceride and cholesterol levels should be checked before starting Lexiva and regularly during treatment. It may be necessary for your health care provider to treat high cholesterol and triglycerides with other medications.
Pregnancy: No information in human pregnancy. Use of Lexiva without Norvir during pregnancy is not recommended.
Women-Specific Information: Because Lexiva reduces the levels of some hormonal contraceptives, talk to your health care provider about changing to or adding other methods of contraception if you take Lexiva
Who Produces the Drug: Viiv Healthcare
Web Site for Drug Info: Lexiva
Patient Assistance: Viiv Healthcare Patient Assistance Program

http://www.viivhealthcareforyou.com/

877-784-4842

Viiv Patient Savings Card

Norvir

Brand Name: Norvir
Other Name(s): RTV
Generic Name(s): Ritonavir
Class of Drug: PI
Common Side Effects: Nausea, diarrhea, stomach pain, loss of appetite, headaches, heartburn, fatigue, weakness, dizziness, trouble sleeping, numbness and tingling around the mouth, changes in taste
Serious Side Effects: Liver problems, pancreatitis, lipodystrophy, increased cholesterol and triglycerides, high blood sugar, increased bleeding in people with hemophilia, increased risk of developing abnormal heart rhythms
Special Considerations: Norvir is most commonly used to boost other drugs. Taking Norvir with certain allergy medications, sedatives, heart medications, and migraine medications can increase the risk of their side effects.
Pregnancy: No evidence of human birth defects; use only to boost other HIV drugs. Use of oral solution of Norvir containing alcohol is not recommended during pregnancy.
Women-Specific Information: Some research suggests that women may be more likely than men to experience side effects when taking Norvir, especially nausea, vomiting, aches and fatigue, and numbness and tingling around the mouth
Who Produces the Drug: AbbVie
Web Site for Drug Info: Norvir
Patient Assistance: Norvir Patient Assistance Program

1-800-222-6885

Co-payment assistance program at 800-441-4987

Prezista

Brand Name: Prezista
Other Name(s): DRV
Generic Name(s): Darunavir
Class of Drug: PI
Common Side Effects: Nausea, vomiting, diarrhea, constipation, headaches, rash
Serious Side Effects: Liver problems, lipodystrophy, increased cholesterol and triglycerides, sulfa allergy, high blood sugar, and increased bleeding in people with hemophilia. Severe skin conditions including: Stevens-Johnson syndrome (severe rash accompanied by fever, fatigue, muscle or joint aches, blisters, facial and tongue swelling), toxic epidermal necrolysis (large red blisters that peel), and acute generalized exanthematous pustulosis (large red swollen areas of skin accompanied by fever).
Special Considerations: Liver function should be tested before starting Prezista. Increased liver function monitoring is a good idea for people with hepatitis or other liver problems. Prezista is not recommended for people with severe liver damage.
Pregnancy: No information in human pregnancy. Use of Prezista without Norvir during pregnancy is not recommended.
Women-Specific Information: Because Prezista reduces the levels of some hormonal contraceptives, talk to your health care provider about changing to or adding other methods of contraception if you take Prezista
Who Produces the Drug: Janssen
Web Site for Drug Info: www.prezista.com
Patient Assistance: Prezista Patient Assistance Program 

1-800-652-6227

Co-pay assistance: Patient Savings Program

1-866-961-7169

Reyataz

Brand Name: Reyataz
Other Name(s): ATV
Generic Name(s): Atazanavir
Class of Drug: PI
Common Side Effects: Nausea, vomiting, diarrhea, stomach pain, headaches, rash, jaundice (yellowing of skin and eyes), trouble sleeping, depression, dizziness, muscle aches, fever
Serious Side Effects: Liver problems, lipodystrophy, increased cholesterol and triglycerides, changes in heart rhythm, peripheral neuropathy, kidney stones, increased bleeding in people with hemophilia, gallbladder problems, Stevens-Johnson syndrome (severe skin rash accompanied by fever, fatigue, muscle or joint aches, blisters, facial and tongue swelling)
Pregnancy: No evidence of human birth defects. Use of Reyataz without Norvir during pregnancy is not recommended.
Women-Specific Information: Because Reyataz affects the levels of some hormonal contraceptives, talk to your health care provider about the right birth control pill for you
Who Produces the Drug: Bristol-Myers Squibb
Web Site for Drug Info: www.reyataz.com
Patient Assistance: Patient assistance or 1-888-281-8981

Co-payment assistance or 1-888-281-8981

Viracept

Brand Name: Viracept
Other Name(s): NFV
Generic Name(s): Nelfinavir
Class of Drug: PI
Common Side Effects: Nausea, diarrhea, gas, rash
Serious Side Effects: Liver problems, lipodystrophy, increased cholesterol and triglycerides, high blood sugar, increased bleeding in people with hemophilia
Pregnancy: No evidence of human birth defects. Evidence shows that Viracept is safe in the short-term for mothers and infants.
Women-Specific Information: Because Viracept reduces the levels of some hormonal contraceptives, talk to your health care provider about changing to or adding other methods of contraception if you take Viracept. Research suggests that women taking Viracept are less likely than men to experience diarrhea, but more likely to experience stomach pain, itching, or rash.
Who Produces the Drug: Viiv Healthcare
Web Site for Drug Info: Viracept
Patient Assistance: Viiv Healthcare Patient Assistance Program

http://www.viivhealthcareforyou.com/

877-784-4842

Viiv Patient Savings Card

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This article was provided by The Well Project. Visit The Well Project's Web site to learn more about their resources and initiatives for women living with HIV. The Well Project shares its content with TheBody.com to ensure all people have access to the highest quality treatment information available. The Well Project receives no advertising revenue from TheBody.com or the advertisers on this site. No advertiser on this site has any editorial input into The Well Project's content.
 
See Also
HIV Medications: When to Start and What to Take -- A Guide From TheBody.com
More on HIV Medications

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