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What's New in the Pediatric HIV Treatment Guidelines?

February 12, 2014

Key changes made by the Panel on Antiretroviral Therapy and Medical Management of HIV-Infected Children (the Panel) to update the November 1, 2012, Guidelines for the Use of Antiretroviral Agents in Pediatric HIV Infection are summarized below. Some content has been reorganized and condensed to enhance usability. Throughout the document, text and references have been updated to include new publications where relevant. The terms "mother-to-child transmission (MTCT)" and "prevention of mother-to-child transmission (PMTCT)" have been replaced with "perinatal transmission" and "prevention of perinatal transmission," respectively. Minor revisions have been made in toxicity tables and other sections of the document; all changes are highlighted throughout the PDF version of the guidelines. A link to the Guidelines for the Prevention and Treatment of Opportunistic Infections in HIV-Exposed and HIV-Infected Children (published November 6, 2013), has been inserted in selected areas of the text to refer readers to more detailed information about use of specific antiretroviral (ARV) agents in the context of hepatitis B, hepatitis C, or tuberculosis coinfection (see the Pediatric Opportunistic Infections Guidelines).

Diagnosis of HIV Infection

Clinical and Laboratory Monitoring of Pediatric HIV Infection

When to Start Antiretroviral Therapy

What Drugs to Start: Initial Combination Therapy for Antiretroviral Treatment-Naive Children

What Not to Start: Regimens Not Recommended for Initial Therapy of Antiretroviral-Naive Children

Management of Children Receiving Combination Antiretroviral Therapy

Role of Therapeutic Drug Monitoring in the Management of Pediatric HIV Infection

Antiretroviral Drug Resistance Testing

Pediatric Antiretroviral Drug Information

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