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What's New in the Pediatric Guidelines?

April 3, 2013

Corrections to the Perinatal Guidelines

On January 22, 2013, changes were made to the Perinatal Guidelines to clarify the infant nevirapine (NVP) dosing recommendations.

In the Postpartum Care -- Infant Antiretroviral Prophylaxis section, Table 9. Recommended Neonatal Dosing for Prevention of Mother-to-Child Transmission of HIV was updated to indicate that the NVP prophylaxis doses are presented as the total dose (not mg/kg).

On January 29, 2013, additional clarifying changes were made to the table. The language for the dosing recommendation was changed to "TOTAL for each dose" (modified from "TOTAL dose PO").

On April 3, 2013, an error in the references in the Darunavir section was corrected. Reference 4 was updated.



Key changes made to update the September 14, 2011, version of the guidelines are summarized below. Throughout the revised guidelines, significant updates are highlighted and discussed. The addendum to the guidelines -- Supplement: Safety and Toxicity of Individual Antiretroviral Agents in Pregnancy -- includes updated information from the Antiretroviral Pregnancy Registry and updates on recent studies of various antiretroviral agents in human pregnancy.

Lessons from Clinical Trials of Antiretroviral Interventions to Reduce Perinatal Transmission of HIV and Table 3, Results of Major Studies on Antiretroviral Prophylaxis to Prevent Mother-to-Child Transmission of HIV

Preconception Counseling and Care for HIV-Infected Women of Childbearing Age and Table 4, Drug Interactions Between Hormonal Contraceptives and Antiretroviral Agents

Antepartum Care

Special Considerations Regarding the Use of Antiretroviral Drugs by HIV-Infected Pregnant Women and Their Infants

Intrapartum Care

Postpartum Care




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