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Fact Sheet

FDA-Approved Anti-HIV Medications

Part of HIV and Its Treatment

From AIDSinfo

August 2012

Antiretroviral therapy (ART) is the recommended treatment for HIV infection. ART involves taking a combination of anti-HIV medications (a regimen) daily. A regimen contains three or more anti-HIV medications from at least two different drug classes. Anti-HIV medications prevent HIV from multiplying in the body, which helps people infected with HIV live longer, healthier lives. ART may reduce the risk of transmission of HIV but anti-HIV medications can't cure HIV/AIDS.

The following table lists anti-HIV medications approved by the U.S. Food and Drug Administration (FDA) for treatment of HIV in the United States. The medications are presented by drug class and identified by generic name/acronym and brand name.


Drug Class Generic Name (Acronym) Brand Name Manufacturer FDA Approval Date
Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs)
NNRTIs bind to and alter reverse transcriptase, an enzyme HIV needs to make copies of itself. Delavirdine (DLV) Rescriptor Pfizer April 4, 1997
Efavirenz (EFV) Sustiva Bristol-Myers Squibb Sept. 17, 1998
Etravirine (ETR) Intelence Tibotec Jan. 18, 2008
Nevirapine (NVP) Viramune Boehringer Ingelheim June 21, 1996
Rilpivirine (RPV) Edurant Tibotec Therapeutics May 20, 2011
Nucleoside Reverse Transcriptase Inhibitors (NRTIs)
NRTIs block reverse transcriptase, an enzyme HIV needs to make copies of itself. Abacavir (ABC) Ziagen GlaxoSmithKline Dec. 17, 1998
Didanosine (ddI) Videx
Videx EC (enteric-coated)		 Bristol-Myers Squibb
Bristol-Myers Squibb		 Oct. 9, 1991
Oct. 31, 2000
Emtricitabine (FTC) Emtriva, Coviracil Gilead Sciences July 2, 2003
Lamivudine (3TC) Epivir GlaxoSmithKline Nov. 17, 1995
Stavudine (d4T) Zerit Bristol-Myers Squibb June 24, 1994
Tenofovir DF (TDF) Viread Gilead Sciences Oct. 26, 2001
Zidovudine (ZDV, AZT) Retrovir GlaxoSmithKline March 19, 1987
Protease Inhibitors (PIs)
PIs block HIV protease, an enzyme HIV needs to make copies of itself.
Atazanavir (ATV) Reyataz Bristol-Myers Squibb June 20, 2003
Darunavir (DRV) Prezista Tibotec June 23, 2006
Fosamprenavir (FPV) Lexiva GlaxoSmithKline, Vertex Pharmaceuticals Oct. 20, 2003
Indinavir (IDV) Crixivan Merck March 13, 1996
Nelfinavir (NFV) Viracept Agouron Pharmaceuticals March 14, 1997
Ritonavir (RTV) Norvir Abbott Laboratories March 1, 1996
Saquinavir (SQV) Invirase Hoffmann-La Roche Dec. 6, 1995
Tipranavir (TPV) Aptivus Boehringer Ingelheim June 22, 2005
Fusion Inhibitors
Fusion inhibitors block HIV from entering the CD4 cells of the immune system. Enfuvirtide (T-20) Fuzeon Hoffmann-La Roche, Trimeris March 13, 2003
CCR5 Antagonists
CCR5 entry inhibitors block CCR5, a protein on the CD4 cells that HIV needs to enter the cells. Maraviroc (MVC) Selzentry Pfizer Aug. 6, 2007
Integrase Inhibitors
Integrase inhibitors block HIV integrase, an enzyme HIV needs to make copies of itself. Raltegravir (RAL) Isentress Merck Oct. 12, 2007
Fixed-Dose Combination
Fixed-dose combination tablets contain two or more anti-HIV medications from one or more drug classes. Abacavir, Lamivudine Epzicom GlaxoSmithKline Aug. 2, 2004
Abacavir, Lamivudine, Zidovudine Trizivir GlaxoSmithKline Nov. 14, 2000
Efavirenz, Emtricitabine, Tenofovir DF Atripla Bristol-Myers Squibb, Gilead Sciences July 12, 2006
Emtricitabine, Rilpivirine, Tenofovir DF Complera Gilead Sciences Aug. 10, 2011
Emtricitabine, Tenofovir DF Truvada Gilead Sciences Aug. 2, 2004
Lamivudine, Zidovudine Combivir GlaxoSmithKline Sept. 27, 1997
Lopinavir, Ritonavir Kaletra Abbott Laboratories Sept. 15, 2000

This information is based on the U.S. Department of Health and Human Services' Guidelines for the Use of Antiretroviral Agents in HIV-1-Infected Adults and Adolescents.



This article was provided by AIDSinfo. Visit the AIDSinfo website to find out more about their activities and publications.
 
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