An Overview of Retrovir (Zidovudine, AZT)
February 23, 2018
Brand Name: Retrovir
Zidovudine can cause serious, life-threatening side effects. These include hypersensitivity reaction or rash, a buildup of lactic acid in the blood (lactic acidosis), liver problems, muscle weakness (myopathy), and blood disorders such as extremely reduced numbers of red blood cells (severe anemia) or reduced numbers of white blood cells (neutropenia).
Contact your health care provider right away if you have any of the following symptoms that could be signs of a hypersensitivity reaction:
Contact your health care provider immediately or get emergency medical treatment right away if you have any of the following symptoms that could be signs of liver problems or lactic acidosis:
Contact your health care provider if you have any of the following symptoms of myopathy:
Contact your health care provider right away if you have any of the following symptoms of severe anemia or neutropenia:
Worsening of liver disease (sometimes resulting in death) has occurred in people with both HIV and hepatitis C virus (HCV) infection who were taking HIV medicines and also being treated for HCV infection with interferon with or without ribavirin. If you are taking zidovudine as well as interferon with or without ribavirin and you experience side effects, tell your health care provider.
While taking zidovudine, it is important to keep all of your appointments with your health care provider.
What Is Zidovudine?
Zidovudine is a prescription medicine approved by the U.S. Food and Drug Administration (FDA) for the following uses:
Zidovudine belongs to a class (group) of HIV drugs called nucleoside reverse transcriptase inhibitors (NRTIs). NRTIs block an HIV enzyme called reverse transcriptase. (An enzyme is a protein that starts or increases the speed of a chemical reaction.) By blocking reverse transcriptase, NRTIs prevent HIV from multiplying and can reduce the amount of HIV in the body.
HIV medicines can't cure HIV/AIDS, but taking a combination of HIV medicines (called an HIV regimen) every day helps people with HIV live longer, healthier lives. HIV medicines also reduce the risk of HIV transmission. However, despite use of zidovudine to prevent mother-to-child transmission of HIV, some cases of HIV infection can still occur.
Zidovudine may also be used off-label to treat some conditions associated with human herpesvirus-8 (HHV-8) infection in people with HIV. For information on the off-label HIV-related use of zidovudine, please refer to the HHV-8 section of the Guidelines for the Prevention and Treatment of Opportunistic Infections in HIV-Infected Adults and Adolescents.
What Should I Tell My Health Care Provider Before Taking Zidovudine?
Before taking zidovudine, tell your health care provider:
How Should I Take Zidovudine?
Zidovudine (brand name: Retrovir) comes in the following forms and strengths:
Take zidovudine according to your health care provider's instructions.
Take zidovudine capsules and syrup with or without food.
Vials of zidovudine for IV injection contain 200 mg of zidovudine in a 20 mL solution. (A solution is a mixture of a medicine and a liquid.). Before use, the appropriate dose of zidovudine is drawn from the vial and diluted with a dextrose (sugar)/water solution. The diluted medicine is injected slowly (infused) over a specified period of time through a needle or catheter into a vein.
If you take too much zidovudine, contact your health care provider or local poison control center (1-800-222-1222) right away, or go to the nearest hospital emergency room.
See the FDA drug labels from DailyMed for more information on how to take zidovudine tablets and zidovudine capsules and syrup. (DailyMed is a federal website that includes the most recent drug labels submitted to FDA.) For more information on how to take zidovudine for IV injection, see the drug summary from MedlinePlus.
What Should I Do if I Forget a Dose?
If you are taking zidovudine by mouth and forget a dose, take the missed dose as soon as you remember it. But if it is almost time for your next dose, skip the missed dose and just take your next dose at the regular time. Do not take two doses at the same time to make up for a missed dose.
What Side Effects Can Zidovudine Cause?
Zidovudine may cause side effects. Many side effects from HIV medicines, such as nausea or occasional dizziness, are manageable. See the AIDSinfo fact sheet on HIV Medicines and Side Effects for more information.
Some side effects of zidovudine can be serious. Serious side effects of zidovudine include lactic acidosis, liver problems, myopathy, and blood disorders such as severe anemia or neutropenia. (See the WARNING box above).
Other possible side effects of zidovudine include:
Tell your health care provider if you have any side effect that bothers you or that does not go away.
These are not all the possible side effects of zidovudine. To learn more about possible side effects of zidovudine, read the drug label or package insert or talk to your health care provider or pharmacist.
You can report side effects to FDA at 1-800-FDA-1088 (1-800-332-1088) or online at www.accessdata.fda.gov/scripts/medwatch/.
How Should Zidovudine Be Stored?
Where Can I Find More Information About Zidovudine?
More information about zidovudine is available:
The above Patient Version drug summary is based on the following FDA label(s): Capsule, syrup, tablet (film coated), injection (solution).
[Note from TheBody: This article was originally published by AIDSinfo on Feb. 23, 2018. We have cross-posted it with their permission.]
This article was provided by AIDSinfo. Visit the AIDSinfo website to find out more about their activities and publications.
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